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For most people, pain is an automatic reflex that protects them from damaging stimulus like a hot stove or candle. For example, heat exposure activates pain receptors in the skin, which pass a signal along a sensory neuron to the spinal cord. This activates a motor neuron, which sends a signal to the muscles in the arm, causing it to contract. But nerve damage can send false signals that cause real pain, or prevent individuals from feeling pain when they are injured.

Nerve damage affects approximately 20 million Americans. There more than 100 different types of nerve damage with a range of different causes including compression, trauma, autoimmune diseases, diabetes, motor neuron diseases, nutritional deficiencies, infections, cancer and drug side effects and toxicities. Learn more about the symptoms of and treatments for neuropathic pain with this slideshow.

Fibromyalgia is a syndrome characterized by chronic pain, stiffness, and tenderness of muscles, tendons, and joints without detectable inflammation. It affects an estimated 3 to 6 million Americans. Fibromyalgia is the second most common disorder seen by rheumatologists. It predominantly affects women at a rate of 3.4%, and less commonly, men at 0.5%, children at 1.2% to 6.2%, and the elderly. Prevalence increases with age, and diagnosis is most common between ages 60 and 79, although symptoms are often present years prior to diagnosis. It can occur independently or can be associated with another rheumatic disease, such as systemic lupus or rheumatoid arthritis.

Fibromyalgia is a syndrome characterized by chronic pain, stiffness, and tenderness of muscles, tendons, and joints without detectable inflammation. It affects an estimated 3-6 million Americans. Learn more about diagnosis and management with this slideshow.