Generic Name and Formulations:
Oxybutynin chloride 10% (1g/sachet); topical gel; contains alcohol.
Indications for GELNIQUE:
Overactive bladder (OAB) with urge urinary incontinence, urgency, and frequency.
Apply 1g gel (one sachet) once daily to dry, intact skin on abdomen, upper arm/shoulders, or thighs. Rotate application sites; avoid use of same site on consecutive days. Wash hands after application. Avoid washing area/showering for 1hr after application.
Urinary or gastric retention. Uncontrolled narrow angle glaucoma.
Bladder outflow obstruction. GI obstruction. Decreased GI motility. Ulcerative colitis. Intestinal antony. Gastroesophageal reflux. Esophagitis. Controlled narrow angle glaucoma. Discontinue if skin hypersensitivity or angioedema develops. Monitor for anticholinergic CNS effects; consider discontinuing if occur. Avoid in myasthenia gravis; discontinue if symptoms occur. Hepatic or renal dysfunction. Minimize skin transference: cover application site with clothing if direct contact is anticipated. Exposure to high environmental temperatures. Gel is flammable. Pregnancy. Nursing mothers.
Caution with drugs that can cause or exacerbate esophagitis (eg, bisphosphonates). Additive effects with other anticholinergics.
Dry mouth, application site reactions (eg, pruritus, dermatitis, papules, erythema), urinary tract infection, dizziness, nasopharyngitis, fatigue, headache, constipation, other anticholinergic effects (eg, CNS).
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