Generic Name and Formulations:
Fosinopril sodium, hydrochlorothiazide; 10mg/12.5mg, 20mg/12.5mg; tabs.
Various generic manufacturers
Indications for Fosinopril/Hydrochlorothiazide:
Hypertension. Not for initial therapy.
Give once daily. Usual range: fosinopril: 10–20mg; HCTZ: 12.5–50mg. Severe renal impairment (CrCl<30mL/min): not recommended.
Anuria. Hypersensitivity to ACE inhibitors, sulfonamide-derived drugs.
Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Salt/volume depletion; correct before initiating therapy. Renal or hepatic impairment. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Diabetes. Gout. SLE. Monitor WBCs in renal or collagen vascular disease. Monitor electrolytes, BUN (if high). Pregnancy (Cat.C in 1st trimester; Cat.D in 2nd and 3rd trimester). Nursing mothers: not recommended.
ACE inhibitor + diuretic (thiazide).
Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Antagonized by NSAIDs. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements. May antagonize norepinephrine, methenamine. May potentiate nondepolarizing muscle relaxants. Adjust antidiabetic, antigout medications. ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid tests. Nitritoid reactions with injectable gold.
Headache, cough, fatigue; hyperkalemia, orthostatic hypotension, angioedema (discontinue if occurs).
Formerly known under the brand name Monopril HCT.
Clinical Pain Advisor Articles
- History of Migraine May Be Associated With Higher Risk for Cochlear Disorders
- Radiofrequency Denervation Efficacious in Treating Thoracic Zygapophyseal Joint Pain
- Symptom Severity, Sensory Sensitivity May Indicate Pain Centralization in Chronic Overlapping Pain Conditions
- Stat Consult: Chronic Low Back Pain
- Opioid Misuse May Help Predict Alcohol Dependence Treatment Outcomes
- Consensus Guidelines for the Use of Intravenous Ketamine for Chronic Pain
- Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain
- Labor Epidural Analgesia Linked to Reduced Likelihood of Successful Breastfeeding
- Novel Oral Treatment Safe, Effective for Migraine Headache Relief
- DFN-02 Nasal Spray Safe, Effective for Acute Treatment of Episodic Migraine
- Methadone Improves Short-Term Outcomes Better Than Morphine in Neonatal Abstinence Syndrome
- Addressing Rare Headache Disorders: Acute Confusional Migraine
- Hospital-Owned Practices Associated With Positive Workplace Perceptions Among Staff
- Optimal Strategies for Opioid Weaning After Ambulatory Surgery
- Chinese Traditional Medicine Showed Effectiveness on Pain, Quality of Life in Advanced Cancer