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Metronidazole Injection
Bacterial infections
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Drug Name:

Metronidazole Injection Rx

Generic Name and Formulations:
Metronidazole 500mg/100mL; soln for IV infusion; contains sodium.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Metronidazole Injection:

Susceptible serious anaerobic infections. Surgical prophylaxis.

Adult:

Infuse over 1hr. Anaerobic infections: 15mg/kg (loading dose), then 7.5mg/kg every 6hrs for 7–10 days; max 4g/24hrs. Bone/joint, lower respiratory tract, endocardium infections: may need to treat longer. Prophylaxis: 15mg/kg 1hr before surgery, then 7.5mg/kg at 6hrs and 12hrs after 1st dose. Severe hepatic impairment: reduce dose by 50%. Hemodialysis: consider dose supplementation after session.

Children:

Not established.

Contraindications:

Pregnancy (1st trimester for trichomoniasis). Within 2 weeks of disulfiram (possible psychotic reactions). Concomitant alcohol during or at least 3 days after treatment.

Warnings/Precautions:

Discontinue if abnormal neurological symptoms occur. Candidiasis. History of blood dyscrasias. Monitor for leukopenia; do CBCs before, during and after therapy. IV: risk of severe/fatal hepatotoxicity in Cockayne Syndrome; obtain LFTs (at baseline, within first 2–3 days after starting, frequently during therapy, and after completion); discontinue if elevated. Hepatic or renal impairment; monitor. Elderly: monitor serum levels. Pregnancy (Cat.B). Nursing mothers: not recommended.

See Also:

FLAGYL

FLAGYL 375

Pharmacological Class:

Nitroimidazole.

Interactions:

See Contraindications. May potentiate oral anticoagulants, lithium; monitor. Avoid concomitant busulfan; if needed, adjust busulfan dose and monitor. May be antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. May be potentiated by cimetidine, other hepatic enzyme inhibitors. IV: may potentiate 5-FU, vecuronium, CYP3A4 substrates (eg, amiodarone, tacrolimus, cyclosporine,carbamazepine, phenytoin, quinidine); monitor. May interfere with serum chemistry tests.

Adverse Reactions:

Nausea, headache, anorexia, vomiting, metallic taste, dysuria, cystitis; seizures, encephalopathy, optic/peripheral neuropathy, aseptic meningitis.

How Supplied:

Tabs—50, 100; Caps 375mg—50; IV—contact supplier

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