• Arthritis/rheumatic disorders

Arthritis/rheumatic disorders:

Indications for TRILURON:

Treatment of pain in osteoarthritis of the knee in patients who have failed nonpharmacologic therapy and analgesics (eg, acetaminophen).

Adult:

Prior to treatment: remove joint effusion (use separate syringe), if present; and give local anesthetic (eg, lidocaine) by SC inj. Inject 2mL intra-articularly in each affected knee weekly for 3 weeks. Use separate vial/syringe for each knee.

Children:

Not established.

Contraindications:

Infection or skin disease at inj site.

Warnings/Precautions:

Treatment cycle <3 injections: not established. Avian protein, feather, egg allergy. Avoid strenuous activity within 48hrs after injection. Pregnancy. Nursing mothers.

Pharmacologic Class:

Hyaluronan.

Interactions:

Avoid disinfectants with quaternary ammonium salts. Concomitant other intra-articular injectables: not recommended.

Adverse Reactions:

Gastrointestinal complaints, inj site pain, headache, local skin reactions, knee swelling/effusion, pruritus; transient knee inflammation.

Generic Availability:

NO

How Supplied:

Single-use vials—1; Single-use prefilled syringes—1