Angina:
Indications for TOPROL-XL:
Long-term management of angina.
Adult Dosage:
Initially 100mg once daily. May increase at 1-week intervals; max 400mg/day.
Children Dosage:
Not recommended.
TOPROL-XL Contraindications:
Severe bradycardia. Heart block >1st degree. Cardiogenic shock. Overt heart failure. Sick sinus syndrome (unless paced).
Boxed Warning:
Ischemic heart disease.
TOPROL-XL Warnings/Precautions:
Mild or compensated heart failure. Ischemic heart or peripheral vascular disease. Bronchospastic disease. Hepatic impairment. Surgery. Diabetes. Hyperthyroidism. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
TOPROL-XL Classification:
Beta-blocker.
TOPROL-XL Interactions:
May potentiate hypotension with prazosin, reserpine, hydralazine, cimetidine, antithyroid drugs. May increase cardiac effects of verapamil, lidocaine. Indomethacin, barbiturates, rifampin may decrease effectiveness. Potentiated by felodipine, possibly quinidine, fluoxetine, paroxetine, propafenone. May block epinephrine.
Adverse Reactions:
Fatigue, dizziness, rash, depression, GI upset, dyspnea, bradycardia, cold extremities, palpitations, CHF, edema, syncope, chest pain, hypotension, bronchospasm, heart block, MI, angina.
How Supplied:
Tabs—100
Pricing for TOPROL-XL
CHF and arrhythmias:
Indications for TOPROL-XL:
Stable, symptomatic (NYHA Class II or III) ischemic, hypertensive, or cardiomyopathic heart failure.
Adult Dosage:
Class II: initially 25mg once daily; more severe: 12.5mg once daily. May double dose as tolerated every 2 weeks; reduce if symptomatic bradycardia occurs; max 200mg/day.
Children Dosage:
Not recommended.
TOPROL-XL Contraindications:
Severe bradycardia. Heart block >1st degree. Cardiogenic shock. Overt heart failure. Sick sinus syndrome (unless paced).
Boxed Warning:
Ischemic heart disease.
TOPROL-XL Warnings/Precautions:
Mild or compensated heart failure. Ischemic heart or peripheral vascular disease. Bronchospastic disease. Hepatic impairment. Surgery. Diabetes. Hyperthyroidism. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
TOPROL-XL Classification:
Beta-blocker.
TOPROL-XL Interactions:
May potentiate hypotension with prazosin, reserpine, hydralazine, cimetidine, antithyroid drugs. May increase cardiac effects of verapamil, lidocaine. Indomethacin, barbiturates, rifampin may decrease effectiveness. Potentiated by felodipine, possibly quinidine, fluoxetine, paroxetine, propafenone. May block epinephrine.
Adverse Reactions:
Fatigue, dizziness, rash, depression, GI upset, dyspnea, bradycardia, cold extremities, palpitations, CHF, edema, syncope, chest pain, hypotension, bronchospasm, heart block, MI, angina.
How Supplied:
Tabs—100
Pricing for TOPROL-XL
Hypertension:
Indications for TOPROL-XL:
Hypertension.
Adult Dosage:
Initially 25–100mg once daily, alone or with a diuretic. May increase at 1-week intervals; max 400mg/day.
Children Dosage:
Not recommended.
TOPROL-XL Contraindications:
Severe bradycardia. Heart block >1st degree. Cardiogenic shock. Overt heart failure. Sick sinus syndrome (unless paced).
Boxed Warning:
Ischemic heart disease.
TOPROL-XL Warnings/Precautions:
Mild or compensated heart failure. Ischemic heart or peripheral vascular disease. Bronchospastic disease. Hepatic impairment. Surgery. Diabetes. Hyperthyroidism. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
TOPROL-XL Classification:
Cardioselective beta-blocker.
TOPROL-XL Interactions:
May potentiate hypotension with prazosin, reserpine, hydralazine, cimetidine, antithyroid drugs. May increase cardiac effects of verapamil, lidocaine. Indomethacin, barbiturates, rifampin may decrease effectiveness. Potentiated by felodipine, possibly quinidine, fluoxetine, paroxetine, propafenone. May block epinephrine.
Adverse Reactions:
Fatigue, dizziness, rash, depression, GI upset, dyspnea, bradycardia, cold extremities, palpitations, CHF, edema, syncope, chest pain, hypotension, bronchospasm, heart block, MI, angina.
How Supplied:
Tabs—100
