Miscellaneous urogenital disorders:

Indications for THIOLA:

In combination with high fluid intake, alkali and diet modification, to prevent cystine stone formation in patients with severe homozygous cystinuria who are not responsive to these measures alone.

Adult:

Give in 3 divided doses at least 1hr before or 2hrs after meals. EC tabs: swallow whole. Initially 800mg/day; usual dose 1000mg/day. Measure urinary cystine at 1 month after initiation, and every 3 months thereafter. Adjust dose to maintain urinary cystine levels <250mg/L. Severe toxicity to d-penicillamine: may start with lower dose.

Children:

<20kg: not established. ≥20kg: Give in 3 divided doses at least 1hr before or 2hrs after meals. EC tabs: swallow whole. Initially 15mg/kg/day. Avoid doses >50mg/kg per day (increased risk of proteinuria). Measure urinary cystine at 1 month after initiation, and every 3 months thereafter. Adjust dose to maintain urinary cystine levels <250mg/L. Severe toxicity to d-penicillamine: may start with lower dose.

Warnings/Precautions:

Monitor urinary protein prior to initiation, then every 3 to 6 months during treatment; discontinue if proteinuria occurs. Monitor renal function. Elderly. Pregnancy. Nursing mothers: not recommended.

See Also:

Pharmacologic Class:

Reducing agent.

Interactions:

EC tabs: avoid alcohol 2hrs before and 3hrs after dose.

Adverse Reactions:

Nausea, diarrhea or soft stools, oral ulcers, rash, fatigue, fever, arthralgia, proteinuria, emesis; hypersensitivity reactions, hypogeusia.

Generic Availability:

NO

How Supplied:

Tabs—100; EC tabs 100mg—300; 300mg—90

Pricing for THIOLA

100mg tablet (Qty: 90)
Appx. price $2522
GoodRx