Constipation and bowel cleansers:

Indications for SUPREP:

Bowel cleansing before colonoscopy.


Start the evening before colonoscopy: dilute 1 bottle to 16oz with water and drink entire amount. Drink 32oz of water over the next hour. Next morning: repeat using the second bottle. Complete prep at least 2hrs before colonoscopy.


Not established.


GI obstruction or perforation. Gastric retention. Toxic colitis. Toxic megacolon. Ileus.


Maintain adequate hydration. Correct electrolyte abnormalities before use. Renal impairment; monitor baseline and post-colonoscopy electrolytes, creatinine, BUN. History of QT prolongation, uncontrolled arrhythmias, recent MI, unstable angina, CHF, or cardiomyopathy: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. Gout. Seizure. Inflammatory bowel disease. Severe ulcerative colitis. Impaired gag reflex. Risk of regurgitation or aspiration. Pregnancy (Cat.C). Nursing mothers.

Pharmacologic Class:

Osmotic laxative.


Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Caution with drugs that may increase risk of electrolyte abnormalities, arrhythmias or QT prolongation. Drugs administered within 1 hour of start of Suprep may not be absorbed.

Adverse Reactions:

Overall discomfort, abdominal distention and pain, nausea, vomiting; transient elevated uric acid, mucosal ulcerations and ischemic colitis.

Generic Availability:


How Supplied:

Bowel prep kit—1 (2 x 6oz bottles of soln w. mixing container)