Indications for SONATA:
Short-term treatment of insomnia.
Usually 10mg immediately prior to bedtime (at least 4hrs before becoming active again); max 20mg. Mild-to-moderate hepatic impairment, concomitant cimetidine, or low weight patients: 5mg. Elderly, debilitated: 5mg; max 10mg. Max 1month/℞. Effect delayed if taken with high-fat/heavy meals.
Reevaluate if insomnia fails to remit after 7–10 days of use. Abnormal thinking and behavioral changes. Depression. Suicidal tendencies. Compromised respiratory function, mild-to-moderate hepatic impairment, debilitated: monitor closely. Severe hepatic impairment: not recommended. Conditions that affect metabolism or hemodynamic response. Write ℞ for smallest practical amount. Drug or alcohol abuse. Elderly (higher risk of falls). Labor & delivery. Pregnancy, nursing mothers: not recommended.
Potentiates CNS depression with alcohol, other CNS depressants. Efficacy may be compromised by drug(s) that induce CYP3A4. May be potentiated by drugs that inhibit aldehyde oxidase (eg, cimetidine, possibly diphenhydramine). May be antagonized by promethazine.
Headache, GI upset, abdominal pain, dizziness, somnolence, migraine; CNS effects, complex behaviors (eg, sleep-driving), anaphylaxis, angioedema, others (see full labeling).