Indications for Pyrazinamide:
Susceptible pulmonary tuberculosis.
Adults and Children:
15–30mg/kg once daily; max 2g daily. Or 50–70mg/kg twice weekly based on lean body weight.
Severe hepatic damage. Acute gout.
Use with other antituberculars. Monitor hepatic function and serum uric acid before and during therapy. Hepatocellular damage or hyperuricemia with acute gouty arthritis: discontinue. Patients at risk for hepatitis (eg, alcoholism). Diabetes (blood glucose may be harder to control). HIV: see literature. Pregnancy (Cat.C). Nursing mothers.
May interfere with Acetest or Ketostix.
Hepatitis, liver dysfunction, gout, GI disturbances, arthralgia, myalgia, blood dyscrasias (rare).