Anemias:

Indications for OXBRYTA:

Sickle cell disease in patients aged ≥12yrs.

Adult:

Swallow whole. 1500mg once daily. Severe hepatic impairment: 1000mg once daily. Avoid concomitant strong CYP3A4 inhibitors or fluconazole; if unavoidable, reduce dose to: 1000mg once daily. Avoid concomitant strong or moderate CYP3A4 inducers; if unavoidable, increase dose to: 2500mg once daily.

Children:

<12yrs: not established.

Warnings/Precautions:

Severe hepatic impairment: reduce dose (see Adults). Pregnancy. Nursing mothers: not recommended (during and for ≥2 weeks after the last dose).

Pharmacologic Class:

Hemoglobin S polymerization inhibitor.

Interactions:

May be potentiated by strong CYP3A4 inhibitors or fluconazole; reduce voxelotor dose (see Adults). May be antagonized by strong or moderate CYP3A4 inducers; increase voxelotor dose (see Adults). Avoid concomitant sensitive CYP3A4 substrates with a narrow therapeutic index; if unavoidable, consider dose reduction of the substrate. May interfere with measurement of Hb subtypes by high-performance liquid chromatography.

Adverse Reactions:

Headache, diarrhea, abdominal pain, nausea, fatigue, rash, pyrexia; hypersensitivity reactions (discontinue if occur).

Generic Availability:

NO

How Supplied:

Tabs—90

Pricing for OXBRYTA

500mg tablet (Qty: 60)
Appx. price $7093
GoodRx