Nonnarcotic analgesics:

Indications for GRALISE:

Postherpetic neuralgia.

Adult:

Swallow whole; do not crush, split or chew tabs. Take once daily with the evening meal. ≥18yrs: initially 300mg on Day 1, 600mg on Day 2, 900mg on Days 3–6, 1200mg on Days 7–10, 1500mg on Days 11–14, titrate up to 1800mg on Day 15. Renal impairment: CrCl 30–60mL/min: 600–1800mg. CrCl <30mL/min or on hemodialysis: not recommended.

Children:

<18yrs: not established.

Warnings/Precautions:

Not interchangeable with other gabapentin products. Epilepsy. Increased risk of suicidal thoughts/behavior. Monitor for worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Multiorgan hypersensitivity. Renal impairment. Avoid abrupt cessation; if discontinuing, withdraw gradually over 1 week or longer. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Increased risk for serious respiratory depression when concomitant CNS depressants, opioids. May affect or be affected by hydrocodone. Potentiated by morphine. Separate dosing of aluminum- or magnesium-containing antacids by at least 2hrs. May cause false (+) results with urine protein tests (eg, Multistix SG).

Adverse Reactions:

Dizziness, somnolence, headache, lethargy, peripheral edema, diarrhea, dry mouth, pain in extremity.

How Supplied:

Tabs—90; 30-Day Starter pack—78 (9 x 300mg + 69 x 600mg)

Pricing for GRALISE

600mg tablet (Qty: 90)
Appx. price $866
GoodRx