• Bacterial infections

Bacterial infections:

Indications for FETROJA:

Susceptible complicated urinary tract infections (cUTI), including pyelonephritis.

Adult:

Give by IV infusion over 3hrs. Treat for 7–14 days. ≥18yrs (CrCl 60–119mL/min): 2g every 8hrs. (CrCl 30–59mL/min): 1.5g every 8hrs. (CrCl 15–29mL/min): 1g every 8hrs. ESRD (CrCl <15mL/min) with or without hemodialysis: 0.75g every 12hrs. (CrCl ≥120mL/min): 2g every 6hrs.

Children:

<18yrs: not established.

Warnings/Precautions:

Increase in all-cause mortality (see full labeling). Reserve for use in those who have limited or no alternative treatment options. Penicillin or other beta-lactam allergy. Discontinue if an allergic reaction occurs. Seizure disorder. Other CNS reactions (eg, nonconvulsive status epilepticus, encephalopathy, coma). Renal impairment: monitor. Elderly: monitor renal function. Pregnancy. Nursing mothers.

Pharmacologic Class:

Cephalosporin.

Interactions:

May cause false (+) results in dipstick tests (urine protein, ketones, occult blood); use alternative methods to confirm (+) tests.

Adverse Reactions:

Diarrhea, infusion site reactions, constipation, rash, candidiasis, cough, elevations in liver tests, headache, hypokalemia, nausea, vomiting; C. difficile-associated diarrhea, hypersensitivity reactions.

Elimination:

Renal (98.6%). Fecal (2.8%). Half-life: 2–3 hours.

Generic Availability:

NO

How Supplied:

Single-dose vials—10

Pricing for FETROJA

1g vial (Qty: 1)
Appx. price $197
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