Constipation and bowel cleansers:
Indications for CLENPIQ:
Bowel cleansing before colonoscopy.
Adults and Children:
<9yrs: not established. ≥9yrs: Split-Dose regimen: take 1st dose during the evening before colonoscopy (eg, 5:00pm to 9:00pm); followed by five or more 8oz cups of clear liquids within 5hrs and before bed. Take 2nd dose the next day, start approximately 5hrs before colonoscopy followed by at least four or more 8oz cups of clear liquids up to 2hrs before the procedure.
Severe renal impairment (CrCl <30mL/min). GI obstruction. Ileus. Bowel perforation. Toxic colitis or megacolon. Gastric retention.
Correct fluid/electrolyte abnormalities before use. CHF. History or risk of seizures. Alcohol or benzodiazepine withdrawal. Known or suspected hyponatremia. Renal impairment; consider baseline and post-colonoscopy lab tests. Increased risk of arrhythmias; consider pre-dose and post-colonoscopy ECGs. Mucosal ulcerations may occur; consider when interpreting findings in inflammatory bowel disease. Rule out GI obstruction/perforation before administering. Severe active ulcerative colitis. Impaired gag reflex. Risk of regurgitation or aspiration. Maintain adequate hydration. Pregnancy. Nursing mothers.
Stimulant + osmotic laxative.
Other laxatives, alcohol, red- or purple-colored drink: not recommended. Caution with drugs that increase risk of fluid/electrolyte abnormalities, QT prolongation, or that affect renal function (eg, diuretics, NSAIDs, ACEIs, ARBs). Oral drugs given within 1hr of start of administration may not be absorbed. Separate dosing of tetracyclines, fluoroquinolones, iron, digoxin, chlorpromazine, or penicillamine by at least 2hrs before or >6hrs after Clenpiq. Antibiotics may reduce efficacy. Caution with drugs that lower seizure threshold. Increased risk of colonic mucosal ulcerations or ischemic colitis with concomitant additional stimulant laxatives.
Nausea, headache, vomiting; children: also abdominal pain.
Generic Drug Availability:
Bottles (160mL)—2 (w. dosing cup)