Indications for Cefotaxime:
Susceptible bacteremia, septicemia, lower respiratory and genitourinary tracts, skin and skin structure, bone and joint, gynecologic, CNS (eg, meningitis), intraabdominal infections. Surgical prophylaxis.
Uncomplicated infections: 1g every 12 hours. Moderate-to-severe infections: 1–2g every 8 hours. Infections commonly needing a higher dosage (eg, septicemia): 2g IV every 6–8 hours. Life-threatening infections: 2g IV every 4 hours. Gonococcal urethritis or cervicitis: 0.5g IM once. Rectal gonorrhea: 0.5g (women) or 1g (men) IM once. All: max 12g/day. Post-op prophylaxis: give 1g as single dose 30–90mins before surgery. Cesarean section: 1st dose: 1g IV as soon as umbilical cord clamped; 2nd and 3rd dose: 1g at 6 and 12 hours after 1st dose. CrCl <20mL/min/1.73m2: consider reducing dose by one-half.
Neonates up to 1 week of age: 50mg/kg IV every 12 hours. 1–4 weeks of age: 50mg/kg IV every 8 hours. Over 1 month of age (<50kg): 50–180mg/kg in 4–6 equally divided doses. ≥50kg: as adult; max 12g/day.
Penicillin or other allergy. Monitor blood counts in treatments >10 days. Renal impairment, reduce dose. GI disease (esp. colitis). Avoid extravasation. Pregnancy (Cat.B). Nursing mothers.
Increased nephrotoxicity with concomitant aminoglycosides, NSAIDs, furosemide. Potentiated by probenecid; avoid cefotaxime doses >6g/day. May cause false (+) Fehling's or Benedict's soln, Clinitest, or Coomb's test.
Inj site reactions, colitis, diarrhea, nausea, vomiting, hypersensitivity (discontinue if occurs); blood dyscrasias, elevated liver enzymes (rare).
Formerly known under the brand name Claforan.