Select therapeutic use:

Arthritis/rheumatic disorders:

Indications for ANAPROX DS:

Rheumatoid arthritis. Osteoarthritis. Ankylosing spondylitis. Polyarticular juvenile idiopathic arthritis (JIA). Tendinitis. Bursitis. Acute gout.

Adult:

Use lowest effective dose for shortest duration. Arthritis, spondylitis: 275mg or 550mg twice daily. Tendinitis, bursitis: Initially 550mg, then 550mg every 12hrs or 275mg every 6–8hrs; max 1.375g (first day), then max 1.1g/day. Acute gout: 825mg once then 275mg every 8hrs. Renal or hepatic impairment, elderly: consider lower doses.

Children:

<2yrs: not established. ≥2yrs: use susp form of naproxen.

Contraindications:

Aspirin allergy. Coronary artery bypass graft surgery.

Boxed Warning:

Risk of serious cardiovascular and gastrointestinal events.

Warnings/Precautions:

Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure, advanced renal disease; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Hepatic or renal impairment. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Dehydration. Hypovolemia. Moderate-to-severe renal impairment (CrCl <30mL/min): not recommended. Hyperkalemia. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic, renal, and ocular function in long-term therapy. Pre-existing asthma. May mask signs of infection or fever. Discontinue at 1st sign of rash or any other hypersensitivity. Elderly. Debilitated. Labor & delivery. May be associated with a reversible delay in ovulation in females of reproductive potential. Pregnancy (3rd trimester; avoid). Nursing mothers.

See Also:

    Pharmacologic Class:

    NSAID (propionic acid deriv.).

    Interactions:

    Concomitant aspirin, salicylates (eg, diflunisal, salsalate), or other NSAIDs: not recommended. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors, ARBs, or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. Concomitant with pemetrexed may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. Avoid antacids, sucralfate, cholestyramine. Serum levels increased by probenecid. May potentiate protein-bound drugs (eg, phenytoin, sulfonylureas, sulfonamides). May interfere with 5HIAA urinary assays or Porter-Silber tests.

    Adverse Reactions:

    Dyspepsia, abdominal pain, nausea, headache, rash, ecchymosis, and edema; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypersensitivity reactions, serious skin reactions (eg, Stevens-Johnson Syndrome, toxic epidermal necrolysis), anemia.

    Generic Availability:

    YES

    How Supplied:

    Tabs—100

    Pricing for ANAPROX DS

    550mg tablet (Qty: 20)
    Appx. price $12
    GoodRx

    Dysmenorrhea:

    Indications for ANAPROX DS:

    Dysmenorrhea.

    Adult:

    Use lowest effective dose for shortest duration. Initially 550mg, then 550mg every 12hrs or 275mg every 6–8hrs; max 1.375g (first day), then max 1.1g/day. Renal or hepatic impairment, elderly: consider lower doses.

    Children:

    Not applicable.

    Contraindications:

    Aspirin allergy. Coronary artery bypass graft surgery.

    Boxed Warning:

    Risk of serious cardiovascular and gastrointestinal events.

    Warnings/Precautions:

    Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure, advanced renal disease; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Hepatic or renal impairment. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Dehydration. Hypovolemia. Moderate-to-severe renal impairment (CrCl <30mL/min): not recommended. Hyperkalemia. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic, renal, and ocular function in long-term therapy. Pre-existing asthma. May mask signs of infection or fever. Discontinue at 1st sign of rash or any other hypersensitivity. Elderly. Debilitated. Labor & delivery. May be associated with a reversible delay in ovulation in females of reproductive potential. Pregnancy (3rd trimester; avoid). Nursing mothers.

    See Also:

      Pharmacologic Class:

      NSAID (propionic acid deriv.).

      Interactions:

      Concomitant aspirin, salicylates (eg, diflunisal, salsalate), or other NSAIDs: not recommended. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors, ARBs, or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. Concomitant with pemetrexed may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. Avoid antacids, sucralfate, cholestyramine. Serum levels increased by probenecid. May potentiate protein-bound drugs (eg, phenytoin, sulfonylureas, sulfonamides). May interfere with 5HIAA urinary assays or Porter-Silber tests.

      Adverse Reactions:

      Dyspepsia, abdominal pain, nausea, headache, rash, ecchymosis, and edema; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypersensitivity reactions, serious skin reactions (eg, Stevens-Johnson Syndrome, toxic epidermal necrolysis), anemia.

      Generic Availability:

      YES

      How Supplied:

      Tabs—100

      Pricing for ANAPROX DS

      550mg tablet (Qty: 20)
      Appx. price $12
      GoodRx

      Nonnarcotic analgesics:

      Indications for ANAPROX DS:

      Pain.

      Adult:

      Use lowest effective dose for shortest duration. Initially 550mg, then 550mg every 12hrs or 275mg every 6–8hrs; max 1.375g (first day), then max 1.1g/day. Renal or hepatic impairment, elderly: consider lower doses.

      Children:

      <2yrs: not established. ≥2yrs: use susp form of naproxen.

      Contraindications:

      Aspirin allergy. Coronary artery bypass graft surgery.

      Boxed Warning:

      Risk of serious cardiovascular and gastrointestinal events.

      Warnings/Precautions:

      Increased risk of serious cardiovascular events (including MI, stroke). Avoid in recent MI, severe heart failure, advanced renal disease; if necessary, monitor. Increased risk of serious GI adverse events (including inflammation, bleeding, ulceration, perforation). History of ulcer disease and/or GI bleeding. Hypertension; monitor BP closely. Hepatic or renal impairment. Discontinue if signs/symptoms of liver disease develop, or if abnormal LFTs persist or worsen. Dehydration. Hypovolemia. Moderate-to-severe renal impairment (CrCl <30mL/min): not recommended. Hyperkalemia. Coagulation disorders. Monitor CBCs, blood chemistry, hepatic, renal, and ocular function in long-term therapy. Pre-existing asthma. May mask signs of infection or fever. Discontinue at 1st sign of rash or any other hypersensitivity. Elderly. Debilitated. Labor & delivery. May be associated with a reversible delay in ovulation in females of reproductive potential. Pregnancy (3rd trimester; avoid). Nursing mothers.

      See Also:

        Pharmacologic Class:

        NSAID (propionic acid deriv.).

        Interactions:

        Concomitant aspirin, salicylates (eg, diflunisal, salsalate), or other NSAIDs: not recommended. Increased risk of GI bleed with anticoagulants, antiplatelets, oral corticosteroids, SSRIs, SNRIs, smoking, alcohol, or prolonged NSAID therapy; monitor. May antagonize, or increase risk of renal failure with diuretics (eg, loop or thiazides), ACE inhibitors, ARBs, or β-blockers; monitor closely. Potentiates digoxin; monitor levels. May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. Concomitant with pemetrexed may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity. Avoid antacids, sucralfate, cholestyramine. Serum levels increased by probenecid. May potentiate protein-bound drugs (eg, phenytoin, sulfonylureas, sulfonamides). May interfere with 5HIAA urinary assays or Porter-Silber tests.

        Adverse Reactions:

        Dyspepsia, abdominal pain, nausea, headache, rash, ecchymosis, and edema; cardiovascular thrombotic events, GI ulcer/bleed, hepatotoxicity, renal toxicity, hypersensitivity reactions, serious skin reactions (eg, Stevens-Johnson Syndrome, toxic epidermal necrolysis), anemia.

        Generic Availability:

        YES

        How Supplied:

        Tabs—100

        Pricing for ANAPROX DS

        550mg tablet (Qty: 20)
        Appx. price $12
        GoodRx