Muscle spasms:

Indications for AMRIX:

Adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

Adult:

Swallow whole; or may sprinkle contents on applesauce and swallow immediately without chewing. Take at same time each day. 15mg once daily; may increase to 30mg/day given once daily. Max 2–3 weeks.

Children:

Not established.

Contraindications:

Acute post-MI. Arrhythmias, heart block, other conduction disturbances. CHF. Hyperthyroidism. During or within 14 days of MAOIs.

Warnings/Precautions:

Not effective in treating spasticity associated with cerebral or spinal chord disease or in children with cerebral palsy. Consider discontinuing if significant CNS symptoms develop. Urinary retention. Angle-closure glaucoma. Increased intraocular pressure. Hepatic impairment or elderly: not recommended. Pregnancy. Nursing mothers.

Pharmacologic Class:

Muscle relaxant (central).

Interactions:

See Contraindications. Hypertensive crisis with MAOIs. Increased risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, tricyclic antidepressants, tramadol, bupropion, meperidine, verapamil, MAOIs); discontinue if occurs. May potentiate alcohol, barbiturates, other CNS depressants. Caution with anticholinergics. May antagonize guanethidine and similar acting compounds. May enhance seizure risk with concomitant tramadol.

Adverse Reactions:

Dry mouth, dizziness, fatigue, constipation, nausea, dyspepsia, somnolence; serotonin syndrome, cardiovascular effects.

How Supplied:

Caps—60

Pricing for AMRIX

15mg capsule (Qty: 30)
Appx. price $236
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