Select therapeutic use:
  • Edema
  • Hypertension

Edema:

Indications for ALDACTAZIDE:

Edema.

Adult:

Not for initial therapy. Usual maintenance: 100mg each of spironolactone and HCTZ daily in single or divided doses. Range: 25mg–200mg of each component daily based on response to initial titration.

Children:

Not established.

Contraindications:

Anuria. Renal impairment. Hypercalcemia. Hyperkalemia. Addison’s disease. Sulfonamide allergy. Acute or severe hepatic failure.

Boxed Warning:

In toxicity studies, shown to be tumorigenic in rats. Not indicated for initial therapy of edema or hypertension.

Warnings/Precautions:

History of allergy or bronchial asthma. Hyponatremia. Gout. Diabetes. SLE. Postsympathectomy. Acute myopia and secondary angle-closure glaucoma. Monitor electrolytes periodically. Metabolic disturbances. Monitor calcium levels in hypercalcemia. Hepatic impairment. Severe renal disease. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacologic Class:

Diuretic (K+ sparing) + (thiazide).

Interactions:

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, ARBs, aldosterone blockers, NSAIDs, heparin, LMWH. Hypokalemia with corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants, antihypertensives. Reduced response to pressor amines (eg, norepinephrine). May need to adjust insulin or oral hypoglycemic dosage. Caution with cholestyramine. May be antagonized by NSAIDs, acetylsalicylic acid. Digitalis toxicity. May interfere with parathyroid tests.

Adverse Reactions:

Hyperkalemia, gynecomastia, diarrhea, vomiting, nausea, somnolence, dizziness, headache, rash, confusion, fever, ataxia, menstrual changes, gastric ulcers, electrolyte disorders (esp. hypokalemia, hypomagnesemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, adverse lipid values.

How Supplied:

Tabs—100

Pricing for ALDACTAZIDE

25mg/25mg tablet (Qty: 30)
Appx. price $22
GoodRx

Hypertension:

Indications for ALDACTAZIDE:

Hypertension.

Adult:

Not for initial therapy. Usual maintenance: 50–100mg each of spironolactone and HCTZ daily in single or divided doses.

Children:

Not established.

Contraindications:

Anuria. Renal impairment. Hypercalcemia. Hyperkalemia. Addison’s disease. Sulfonamide allergy. Acute or severe hepatic failure.

Boxed Warning:

In toxicity studies, shown to be tumorigenic in rats. Not indicated for initial therapy of edema or hypertension.

Warnings/Precautions:

History of allergy or bronchial asthma. Hyponatremia. Gout. Diabetes. SLE. Postsympathectomy. Acute myopia and secondary angle-closure glaucoma. Monitor electrolytes periodically. Metabolic disturbances. Monitor calcium levels in hypercalcemia. Hepatic impairment. Severe renal disease. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacologic Class:

Diuretic (K+ sparing) + (thiazide).

Interactions:

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, ARBs, aldosterone blockers, NSAIDs, heparin, LMWH. Hypokalemia with corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants, antihypertensives. Reduced response to pressor amines (eg, norepinephrine). May need to adjust insulin or oral hypoglycemic dosage. Caution with cholestyramine. May be antagonized by NSAIDs, acetylsalicylic acid. Digitalis toxicity. May interfere with parathyroid tests.

Adverse Reactions:

Hyperkalemia, gynecomastia, diarrhea, vomiting, nausea, somnolence, dizziness, headache, rash, confusion, fever, ataxia, menstrual changes, gastric ulcers, electrolyte disorders (esp. hypokalemia, hypomagnesemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, adverse lipid values.

How Supplied:

Tabs—100

Pricing for ALDACTAZIDE

25mg/25mg tablet (Qty: 30)
Appx. price $22
GoodRx