Acne:

Indications for ACZONE 7.5%:

Acne vulgaris.

Adults and Children:

<9yrs: not established. Wash skin and pat dry. ≥9yrs: apply pea-sized amount to entire face or other affected area in a thin layer once daily. Rub in gently and completely. Wash hands after use. Reevaluate if no improvement after 12 weeks.

Warnings/Precautions:

Avoid in congenital or idiopathic methemoglobinemia. G6PD deficiency: may have increased risk of methemoglobinemia or hemolytic anemia; discontinue if occurs. Pregnancy. Nursing mothers.

See Also:

Pharmacologic Class:

Sulfone.

Interactions:

Increased risk of hemolysis in G6PD-deficient patients with concomitant trimethoprim/sulfamethoxazole, other folic acid antagonists (eg, pyrimethamine), anticonvulsants, rifampin, St. John's wort. Increased risk of methemoglobinemia with concomitant sulfonamides, acetaminophen, chloroquine, nitrates, nitrites, nitrofurantoin, phenobarbital, phenytoin, primaquine, quinine, and others. Skin/hair discoloration with topical benzoyl peroxide.

Adverse Reactions:

Application site reactions (oiliness, peeling, dryness, erythema, pruritus).

Generic Availability:

NO

How Supplied:

Gel 5% (tubes)—30g, 60g, 90g; Gel 7.5% (pumps)—30g, 60g, 90g