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DDAVP INJECTION
Bleeding disorders
Pituitary disorders
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Drug Name:

DDAVP INJECTION Rx

Generic Name and Formulations:
Desmopressin acetate 4mcg/mL; soln for inj or IV infusion after dilution.

Company:
Ferring Pharmaceuticals, Inc.

Therapeutic Use:

Indications for DDAVP INJECTION:

To maintain hemostasis or to stop bleeding in Hemophilia A and mild-to-moderate Type 1 von Willebrand's disease (VWD), each with >5% Factor VIII activity.

Adults and Children:

<3 months: not recommended. ≥3 months: 0.3micrograms/kg IV over 15–30 minutes. Pre-op: give 30 minutes before scheduled procedure. May repeat dose based on clinical response. Repeated administration before 48hrs associated with tachyphylaxis.

Contraindications:

Moderate to severe renal impairment (CrCl <50mL/min). Hyponatremia, or history of.

Warnings/Precautions:

Not for treating Hemophilia A with Factor VIII coagulant activity levels ≤5%, Hemophilia B, in patients with FVIII antibodies, or for Type IIB VWD, or severe Type 1 VWD and evidence of abnormal molecular form of FVIII antigen. Monitor fluid intake, urine volume plasma osmolality. Fluid/electrolyte imbalance (eg, cystic fibrosis). Adjust fluid intake downward (esp in children and elderly) to decrease risk of water intoxication, hyponatremia. Habitual or psychogenic polydipsia. Coronary artery insufficiency. Hypertension. Predisposition to thrombosis. Pregnancy (Cat.B). Nursing mothers.

Pharmacological Class:

Antidiuretic hormone.

Interactions:

Caution with other pressor agents, drugs that may increase the risk of water intoxication with hyponatremia (eg, tricyclic antidepressants, SSRIs, chlorpromazine, opiates, NSAIDs, lamotrigine, carbamazepine). Possible convulsions with oxybutynin, imipramine.

Adverse Reactions:

Headache, nausea, flushing, abdominal cramps, vulval pain, inj site reaction, water intoxication, hyponatremia, rare: changes in BP, severe allergic reactions, thrombotic events (inj).

How Supplied:

Amp (1mL)—10; Multi-dose vial (10mL)—1

Indications for DDAVP INJECTION:

Central (cranial) diabetes insipidus. Temporary polyuria and polydipsia following head trauma or surgery in the pituitary region.

Adult:

2–4mcg/day SC or IV in 2 divided doses. If switching stabilized patient, use one-tenth of intranasal dose.

Children:

Not recommended.

Contraindications:

Moderate to severe renal impairment (CrCl <50mL/min). Hyponatremia, or history of.

Warnings/Precautions:

Monitor fluid intake, urine volume and osmolality. Fluid/electrolyte imbalance (eg, cystic fibrosis). Habitual or psychogenic polydipsia. Coronary artery insufficiency. Hypertension. Inj: Predisposition to thrombosis. Nasal mucosal changes (nasal forms). Young children. Elderly. Pregnancy (Cat.B). Nursing mothers.

See Also:

DDAVP

DDAVP NASAL SPRAY

DDAVP RHINAL TUBE

Pharmacological Class:

Vasopressin (synthetic).

Interactions:

Caution with other pressor agents, drugs that may increase the risk of water intoxication with hyponatremia (eg, tricyclic antidepressants, SSRIs, chlorpromazine, opiates, NSAIDs, lamotrigine, carbamazepine). Possible convulsions with oxybutynin, imipramine.

Adverse Reactions:

Headache, nausea, flushing, abdominal cramps, vulval pain, water intoxication, hyponatremia, nasal congestion or rhinitis (nasal forms), inj site reaction; rare: changes in BP, severe allergic reactions, seizures in children from plasma hypoosmolality, thrombotic events (inj).

How Supplied:

Tabs—100; Nasal spray—5mL (50 sprays); Rhinal tube—2.5mL (w. 2 rhinal tubes); Amp (1mL)—10; Multi-dose vial (10mL)—1

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