Allopurinol Demonstrates No Analgesic Effect for Fibromyalgia Pain

Woman with pill and water
Woman with pill and water
Allopurinol did not provide pain relief for patients with fibromyalgia pain over the course of 30 days.

The following article is part of conference coverage from the IASP 2018 conference in Boston, Massachusetts. Clinical Pain Advisor’s staff will be reporting breaking news associated with research conducted by leading experts in pain medicine. Check back for the latest news from IASP 2018.

Allopurinol did not provide pain relief for patients with chronic pain from fibromyalgia over the course of 30 days, according to results to be presented at the 17th World Congress on Pain, held September 12-16, 2018, in Boston, Massachusetts.

The researchers of this study investigated whether allopurinol would decrease pain as an adjuvant therapy by inhibiting xanthine oxidase and increasing purinergic activity to affect pain transmission. Female patients with uncontrolled fibromyalgia were randomly assigned to an intervention group that received allopurinol 300 mg twice daily (n=31), or a control group that received placebo twice daily (n=29). Pain sensitivity, anxiety, depression, and functional status were assessed at baseline, 15 days, and 30 days. 

At the 30-day point, pain scores (P >.05), anxiety, depressive symptoms, and functional status had not improved. Patients did not report significant adverse events.

Researchers concluded that allopurinol 300 mg twice daily for 30 days showed no benefit for chronic pain management in this patient population. Future research is needed to analyze selective purine derivatives as advantageous analgesic therapy.

Related Articles

Follow @ClinicalPainAdv


Schmidt A, Schmidt S, Fagundes A, et al. Allopurinol for fibromyalgia pain in adults: a randomized clinical trial. Presented at: 2018 IASP World Congress on Pain; September 12-16, 2018; Boston, MA.

For more coverage of IASP 2018, click here.