Clinical Trials

Standardized Funder Policies Will Improve Transparency, Publication Bias in Clinical Trials

Standardized Funder Policies Will Improve Transparency, Publication Bias in Clinical Trials

By

Research findings suggest the need for greater adherence to a standardized set of policies aimed at improving transparency among clinical trial funders.

Risks and Benefits of FDA "Pre-Cert" Program for Medical Software Devices Examined

Risks and Benefits of FDA "Pre-Cert" Program for Medical Software Devices Examined

By

The FDA Digital Health Software Precertification Program represents a feasible solution to regulate software classified as a medical device.

Addressing Barriers to Translational Pain Research

Addressing Barriers to Translational Pain Research

By

Many translational barriers exist between preclinical research and clinical practice.

ACTTION Consensus Provides Best Practices for the Design of Pediatric Clinical Trials Focused on Acute Pain

ACTTION Consensus Provides Best Practices for the Design of Pediatric Clinical Trials Focused on Acute Pain

By

Key factors susceptible to improve the design of clinical trials on analgesics for acute pain in pediatric populations were reviewed and recommendations published.

Clinical Trials May Overestimate Benefits of Cannabis Therapy

Clinical Trials May Overestimate Benefits of Cannabis Therapy

By

The benefits associated with medical cannabis therapy may be overestimated due to inadequate blinding in clinical trials.

Data Transparency and Publication Bias: Impact on Clinical Trials

Data Transparency and Publication Bias: Impact on Clinical Trials

By

The need for data transparency carries an ethical and moral obligation and requires nonselective and unbiased publication of clinical results.

Reducing the <i>P</i>-Value for Statistical Significance to Improve the Quality of Research?

Reducing the P-Value for Statistical Significance to Improve the Quality of Research?

By

In a controversial and divisive article, a group of researchers proposes to improve "statistical standards of evidence" by lowering the P value from P <.05 to P <.005 in the fields of biomedical and social sciences.

Cancer-specific Reference Values Specified for PROMIS Domains

Cancer-specific Reference Values Specified for PROMIS Domains

Reference values for PROMIS domains have been established by a population-based study.

Measuring Clinically Meaningful Outcomes in Chronic Pain Clinical Trials

Measuring Clinically Meaningful Outcomes in Chronic Pain Clinical Trials

By

Standardized and clinically meaningful outcome measures in clinical trials in chronic pain may enhance efforts to develop effective treatments for chronic pain patients.

Classification of Peripheral Neuropathic Pain Based on Sensory Profiles

Classification of Peripheral Neuropathic Pain Based on Sensory Profiles

By

Researchers identified 3 subgroups of patients with peripheral neuropathic pain, based on sensory signs and symptoms.

The Issues With Clinical Studies That Impede the Development of New Pain Drugs

The Issues With Clinical Studies That Impede the Development of New Pain Drugs

By

Drug development faces 2 major issues: pre-clinical animal efficacy studies do not accurately predict human efficacy, and clinical trials often wrongly fail to show drug efficacy.

Predicting Placebo Response? It May Now be Possible

Predicting Placebo Response? It May Now be Possible

By

Connectivity in the right midfrontal gyrus may help predict placebo response.

Sign Up for Free e-Newsletters