Chronic Pain News Archive
The majority of patients being considered for corticosteroid injections to treat chronic pain may be at high risk for untreated diabetes mellitus.
The level of pain sensitization in the early post-trauma period in patients with complex regional pain syndrome type 1 after distal radius fractures may be associated with the persistence of symptoms.
Healthcare providers at Veterans Affairs centers cite time constraints, logistic constraints, and interpersonal challenges as unique barriers to adherence with practice guidelines when treating patients on long-term opioid therapy.
Analgesic modality used in patients presenting to the emergency department with trauma, including abdominal pain, may not affect the presence of persistent pain at 6 months.
Exercise professionals may act as "key supporters" of individuals with chronic pain.
Individuals with chronic spinal pain, particularly those who are overweight or obese, may be less likely to recover from this condition if both their parents also have chronic spinal pain.
The National Athletic Trainers' Association has issued recommendations for identifying and managing patients with patellofemoral pain.
A stepped-care model of pain management implemented in primary care was successful in increasing the proportion of veteran patients reporting moderate to severe pain, as well as decreasing the use of opioids for pain management.
Patients with greater trochanteric pain syndrome may have altered conditioned pain modulation, as well as a high number of pain locations associated with negative conditioned pain modulation.
Factors underlying participation in the Living Better Beyond Pain, a self-management training program for patients with chronic pain, as well as benefits gained from participating in the program and associated barriers were identified.
Men and women may seek pain relief in both gendered and ungendered ways, depending on whether gender norms or perceptions of analgesic efficacy are thought to define social acceptability.
A "Pain and Stress Management" program for the management of chronic pain, was found to be effective in alleviating pain, diminishing stress, promoting self-management of pain, and ameliorating general well-being.
Specific characteristics in several brain structures and psychological features may predict the magnitude of the placebo response.
In patients with chronic pain conditions, daily pain assessments using a smartphone app indicated a positive correlation between perceived change in pain symptoms and levels of pain catastrophizing.
A self-report screening tool designed to identify impaired psychosocial functioning and behavioral responses in parents of children with chronic pain was found to be useful clinically.
The clinical profiles of patients taking over-the-counter pain medications were found to be poorer than expected, with a high prevalence of migraine headache and many reporting frequent and disabling pain for extended durations.
Patient blinding in randomized placebo-controlled trials on pharmacologic treatments for chronic pain conditions may seldom be assessed.
A population-based, cohort study was conducted to identify knee pain in a group of older adults.
For patients with chronic pain, photo elicitation on social networks may represent a novel way to get a better understanding of lived experiences with chronic pain.
Patients with unilateral complex regional pain syndrome may have a weaker illusory response to a novel finger illusion compared with healthy controls, indicating disrupted weighting of bilateral hand cortical representations.
Patients with multiple sclerosis-related chronic pain were found to have spectral abnormalities within the dynamic pain connectome regions.
In this prospective, cohort study, patients (N=18) were randomized to receive gabapentin 400-800mg 3 times daily then pregabalin 150-300mg twice daily or vice versa; each treatment regimen was taken for 8 weeks with a 1-week washout period in between.
Adverse childhood experiences such as sexual violence, physical violence, serious illness, and bereavement may be associated with urologic chronic pelvic pain syndrome symptoms.
Chronic pain may represent an important contributing factor to suicide.
Invasive procedures may not provide a substantial benefit over sham procedures for the management of chronic back or knee pain.
Single-patient multicrossover (n-of-1) trials supported by mobile health applications may not improve pain interference compared with usual care for patients with chronic musculoskeletal pain.
Patients taking opioid analgesics for chronic noncancer pain may have a risk for unemployment 3-fold higher compared with individuals not taking opioids.
Findings suggest that repeating MRI of the sacroiliac joints after 3 months or 1 year in patients with chronic back pain and suspected axial spondyloarthritis was not useful.
Concurrent use of benzodiazepines and long-term opioids was found in 25% of patients with chronic pain, and to be associated with elevated risk of falling and visiting the emergency department.
Perceptions of injustice may predict worse outcomes in patients with chronic low back pain.
Cigarette smoking at any point during adulthood may be associated with an increased risk for chronic widespread pain.
Kinesiophobia, pain, and physical function may be associated with dynamic balance in individuals with greater trochanteric pain syndrome.
Widespread pressure pain hypersensitivity at nerve trunks and musculoskeletal structures associated with long-standing unilateral plantar heel pain may result from altered central pain processing.
The use of morphine and ziconotide is consistently recommended as first-line intrathecal therapy in the management of cancer- and non-cancerchronic pain, respectively.
Adverse Event Reporting System Effective for Improved Control of Pharmacologic Therapy in Chronic Pain
A pharmacovigilance data recording system of adverse events in patients with long-term opioid use for the management of chronic noncancer pain may be effective for improved control of pharmacologic pain therapy.
Ozone injection, despite slow onset, may provide longer-lasting outcomes compared with corticosteroid for the treatment of chronic plantar fasciitis.
About 20.4 percent of U.S. adults have chronic pain and 8.0 percent have high-impact chronic pain.
In men with HIV, daily social support may improve experiences of pain, and attachment style may influence the ways in which individuals leverage social support as a pain-coping mechanism.
Young women with patellofemoral pain may have altered pain processing compared with healthy controls.
Treating chronic prostatitis/chronic pelvic pain as a psychoneuromuscular disorder may significantly improve related symptoms.
Several biopsychosocial factors as well as temporomandibular disorder (TMD)-related symptoms were found to improve over time in individuals with chronic, but not newly developed TMD.
Pain management in patients with spinal cord injury should be tailored according to pain level and subtype.
Systematic screening for anxiety, disability, and pain can increase psychological referral rates among pediatric patients with abdominal pain.
A low-literacy, pain self-management program delivered one-on-one by a health educator or in groups with lectures from experts over a period of 6 months may improve chronic pain outcomes.
Electroacupuncture may be safe and effective to reduce the use of opioid medications in patients with chronic musculoskeletal pain.
L-Glutamine oral treatment with or without hydroxyurea reduces pain crises better than placebo in individuals with sickle cell disease.
Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
Weekly vigorous activity and cultural engagement may protect against the development of chronic pain in older adults.
The approval was based on data from 2 multinational double-blind, placebo-controlled Phase 3 trials involving 1686 premenopausal women with moderate to severe pain associated with endometriosis.
Investigators examined whether chronic pain and hypoesthesia are linked in patients with MS.
Symptom Severity, Sensory Sensitivity May Indicate Pain Centralization in Chronic Overlapping Pain Conditions
Two composite constructs of symptom patterns in Chronic Overlapping Pain Conditions were found to be associated with each other and the centralized pain phenotype.
A panel of experts formulated consensus guidelines for physicians who use intravenous ketamine infusions to treat chronic pain.
Opioid equianalgesic dosing chart used for interchanging between drug, route of administration, or both.
In adults with sickle cell disease, higher daily opioid use may be associated with poorer health-related quality of life.
In patients with subacromial pain syndrome, ultrasound-guided percutaneous electrolysis plus standard therapy and exercise may not bring additional benefits in terms of disability and pressure sensitivity compared with therapy and exercise alone.
Olinciguat is a soluble guanylate cyclase stimulator currently in Phase 2 development.
Differing formulations and ratios of the subjects' medical cannabis regimens have been accounted for, though further information about ratios of CBD and TCH are subject to change due to continued ongoing research.
Pain in patients with multiple sclerosis may affect their daily functioning regardless of disease severity.
The development of and recovery from chronic pain was found to be highly dependent on a patient's previous history of pain.
Education Plus Exercise, Single Corticosteroid Injection Effective in Long Term for Gluteal Tendinopathy
Education combined with exercise as well as a single corticosteroid injection may be more effective than a wait-and-see approach for alleviating gluteal tendinopathy-associated pain.
Opioids were found to be associated with adverse events in older Medicare beneficiaries on hemodialysis.
Persistent pain — which is common in survivors of critical illnesses — may not be associated with opioid exposure during intensive care unit stay.
A newly developed Web-based platform designed to empower patients with chronic pain and provide them with self-management tools was found to improve self-efficacy and treatment satisfaction when administered in conjunction with nurse and social worker coaching.
Cognitive behavioral therapy-based psychological interventions may provide some benefits in older adults with chronic non-cancer pain.
Interbrain coupling of areas implicated in pain processing may be enhanced when romantic partners hold hands while 1 of the 2 is subjected to pain.
The use of a novel frequency pairing for transcranial magnetic stimulation may effectively relieve upper and lower extremity pain associated with complex regional pain syndrome.
A number of factors including chronic pain co-occurring with posttraumatic stress disorder and pain interference may predict suicidal ideation and violent impulses in US veterans with chronic pain.
Researchers assessed the cross-sectional and longitudinal relationships between elder abuse and neglect and chronic pain.
Neuropsychological performance may not be associated with the improvements in pain interference observed after an 8-week Acceptance and Commitment Therapy program in veterans with chronic pain.
Zohydro ER is also available in 10mg, 15mg, 30mg, 40mg, and 50mg dosage strengths.
Group cognitive behavioral therapy and pain education may be more effective than usual care for improving pain and physical function in patients presenting with chronic pain at low-income clinics.
For patients with chronic pain, literacy-adapted group cognitive behavioral therapy and group pain education improve pain and physical function compared with usual care.
A web-based cognitive behavior therapy program may be associated with greater reductions in aberrant drug-related behavior, pain interference, and pain catastrophizing in patients with chronic pain treated with opioids who undergo treatment as usual compared with patients who undergo treatment as usual only.
For youth with chronic pain, researchers found that sleep quality partially mediated the relationships between PTSD and pain intensity and interference.
Comparative chart of narcotic analgesics including formulations, strengths, and dosing intervals.
Multidisciplinary Social Cognitive Intervention May Improve Quality of Life and Autonomy for Patients With Chronic Pain
An intensive social cognitive intervention delivered by a multidisciplinary team may lead to improvements in health-related quality of life, depressive symptoms, and autonomy in patients with chronic pain.
Age, anxiety, and socioeconomic status are better predictors than race and ethnicity for health-related quality of life outcomes in patients with chronic pain.
Current evidence suggests ketamine may be an effective therapy for the management of chronic noncancer pain.
Health care practitioner groups differ regarding the signs and symptoms that define myofascial pain syndrome, and there is poor agreement among chiropractors, physicians, and massage therapists.
Mental disorders are positively associated with subsequent self-reported chronic back and/or neck pain, with a clear dose-response relationship between the number of mental disorders and subsequent pain.
Patients diagnosed with complex regional pain syndrome (CRPS) demonstrate significant structural and functional brain changes in regions associated with movement and pain.
Symproic tablets for the treatment of opioid-induced constipation in adults with chronic non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent opioid dosage escalation.
Poor sleep quality partially mediates relationships between post-traumatic stress syndrome and severity of chronic pain in pediatric patients.
The use of oxycodone/naloxone prolonged-release tablets (OXN PR) can provide significant relief for patients who suffer from moderate to severe chronic pain and opioid-induced constipation.
In patients with chronic pain, comorbid hypertension may be mediated by reduced heart rate variability and spontaneous baroreflex sensitivity.
Naloxegol was shown to maintain adequate opioid analgesia over a 12-week treatment course, while relieving opioid-induced constipation.
The Intelis platform monitors patient activity 24/7, which means physicians can make treatment adjustments as needed.
NKTR-181 was found to be safe and effective in patients with low back pain.
Sleep-onset insomnia, pain intensity, and daytime dysfunction contribute to risk of suicide in patients diagnosed with chronic pain.
The HIV Medicine Association of the Infectious Disease Society of America recommends that people living with HIV be screened for pain and offered both nonpharmacologic and pharmacologic treatment options.
Drug delivery with an intrathecal bolus is safe for the treatment and management of unpredictable breakthrough pain.
No conclusive evidence was found supporting the efficacy of antidepressants in the pediatric population.
Doxepin was not only found to be effective at improving sleep outcomes, but also generally well tolerated in patients with diverse demographic and baseline characteristics.
Lidocaine infusions were shown to provide long-lasting and adequate analgesia in 41% of patients with chronic pain.
Women with fibromyalgia and chronic widespread pain had elevated levels of childhood adversity, including sexual and emotional abuse.
In patients with severe chronic pain refractory to conventional therapy, intrathecal ziconotide provided long-term pain relief, particularly when used as first-line intrathecal therapy.
Weight gain during early to middle adulthood is associated with an increased risk of major chronic diseases and decreases the likelihood of healthy aging.
The low dose of the microdose method reduces the formation of catheter tip granuloma.
Tanezumab is a NGF inhibitor and is a first-in-class agent to receive Fast Track approval.
Egalet announced the launch of Arymo ER extended-release tablets for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment.
A new clinical practice guideline regarding the use of opioids for chronic pain has been released by the VA and DoD.
Clinical Pain Advisor Articles
- Reviewing the Use of Buprenorphine in Perioperative Pain Management
- IASP Updates Classification of Chronic Pain
- CBT Program Effective for Chronic Pain and Opioid Use Disorder
- Galcanezumab Provides Persistent Preventive Effects in Episodic, Chronic Migraine
- Large Survey Evaluates Effects of Chronic Migraine on Life Domains
- Reviewing the Use of Buprenorphine in Perioperative Pain Management
- External Trigeminal Nerve Stimulation May Alleviate Migraine Pain
- Galcanezumab Provides Persistent Preventive Effects in Episodic, Chronic Migraine
- Pulsed Ultrasound May Be Effective for the Treatment of Rib Fractures
- Greater Walking Frequency, Duration May Reduce Risk for Low Back Pain
- Chronic Secondary Headache or Orofacial Pain IASP Classification
- Ultrasound-Guided C2 Coblation May Be Effective for Cervicogenic Headache
- Case Study: Fever and Headache in an Adolescent Boy
- Racial Disparities May Have Widened After Hospital Readmissions Reduction Program Implementation
- Cervical Dysfunction Needs Clarification to Identify Link With Headache