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Cefuroxime
Bacterial infections
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Drug Name:

Cefuroxime Rx

Generic Name and Formulations:
Cefuroxime (as axetil) 250mg, 500mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Cefuroxime:

Susceptible mild to moderate infections including pharyngitis/tonsillitis, acute maxillary sinusitis, chronic bronchitis, acute otitis media, uncomplicated skin and skin structure, UTIs, gonorrhea, early Lyme disease.

Adult:

Swallow whole. ≥13yrs: Pharyngitis/tonsillitis, sinusitis: 250mg twice daily for 10 days. Acute bacterial exacerbations of chronic bronchitis, skin and skin structure infections: 250–500mg twice daily for 10 days. UTIs: 250mg twice daily for 7–10 days. Gonorrhea: 1g as a single dose. Lyme disease: 500mg twice daily for 20 days. Renal impairment: see full labeling.

Children:

Swallow whole. <13yrs: Otitis media, sinusitis: 250mg twice daily for 10 days.

Contraindications:

β-lactam allergy.

Warnings/Precautions:

Renal impairment. Elderly. Pregnancy (Cat.B). Nursing mothers.

Pharmacological Class:

Cephalosporin.

Interactions:

Potentiated by probenecid; not recommended. May antagonize oral contraceptives; consider non-hormonal methods. Avoid H2-blockers, PPIs. Separate cefuroxime by ≥1hr before or 2hrs after antacids. May interfere with glucose tests.

Adverse Reactions:

Diarrhea, nausea, vomiting, Jarisch-Herxheimer reaction, vaginitis; anaphylactic reactions (discontinue if occur), C.difficile-associated diarrhea.

Note:

Formerly known under the brand name Ceftin.

How Supplied:

Contact supplier

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