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CAVERJECT
Erectile dysfunction
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Drug Name:

CAVERJECT Rx

Generic Name and Formulations:
Alprostadil 20mcg, 40mcg; per vial; lyophilized pwd for intracavernous inj after reconstitution; contains benzyl alcohol.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for CAVERJECT:

Treatment of erectile dysfunction. Adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.

Adult:

Inject into the dorso-lateral aspect in the proximal third of penis, avoid visible veins; rotate inj side and site. Determine optimum dose and give 1st injections in office. Use lowest effective dose. Vasculogenic, psychogenic, or mixed etiology: initially 2.5mcg; if partial response, may increase dose to 5mcg within 1hr; during titration: max 2 doses within 24hr period; if more titration is needed, may give in increments of 5–10mcg at least 24hrs apart until optimal dose is achieved. Usual max: 60mcg. Neurogenic etiology: initially 1.25mcg; if partial response, may increase dose to 2.5mcg within 1hr; during titration: max 2 doses within 24hr period; if more titration is needed, may give 5mcg during the next 24hrs; thereafter, may give doses in increments of 5mcg at least 24hrs apart until optimal dose is achieved. Usual max: 60mcg. Maintenance for home use: max 3 injections/week; allow at least 24hrs between doses. Adjunct in diagnosis: see full labeling.

Children:

Not indicated.

Contraindications:

Predisposition to priapism (eg, sickle cell anemia or trait, multiple myeloma, leukemia). Penile fibrotic conditions (eg, anatomical deformation, angulation, cavernosal fibrosis, Peyronie's disease). Penile implants. Females.

Warnings/Precautions:

Preexisting cardiovascular disease. Evaluate and treat underlying causes prior to initiating therapy. Treat priapism immediately. Patient must not adjust dose on own. Reevaluate every 3 months. Hypotension; avoid in those with known cavernosa venous leakage. Monitor for signs of penile fibrosis. Discontinue if penile angulation or cavernosal fibrosis develops. Risk of needle breakage; use proper handling and injection techniques. Does not protect against sexually transmitted diseases.

Pharmacological Class:

Prostaglandin.

Interactions:

Concomitant vasoactive agents: not established. Concomitant with anticoagulants may increase inj site bleeding.

Adverse Reactions:

Penile pain, prolonged erection, penile fibrosis, inj site hematoma or ecchymosis, penis disorder, penile rash or edema, other local effects, dizziness.

How Supplied:

Single-dose vials—6; Caverject Impulse 10mcg, 20mcg—2 (dual chamber syringe systems + supplies)

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