Generic Name and Formulations:
Fluorouracil 0.5% (0.35% in microspheres); crm.
Valeant Pharmaceuticals, Inc
Indications for CARAC:
Multiple actinic or solar keratoses of the face and anterior scalp.
≥18yrs: Wash and dry area. Wait 10 minutes. Apply thin film to skin where lesions appear once daily for up to 4 weeks. Do not occlude. May apply sunscreen/ moisturizer 2 hours later. Wash hands after use.
<18yrs: not recommended.
Dihydropyrimidine dehydrogenase (DPD) deficiency. Women of childbearing potential. Pregnancy (Cat.X).
Discontinue if symptoms of DPD deficiency develop (e.g., abdominal pain, bloody diarrhea, vomiting, fever, chills). Ulcerated or inflamed skin. Avoid eyes, mucous membranes, exposure to sun or UV light. Nursing mothers: not recommended.
Application site reaction (may persist 2 weeks after drug is stopped), eye irritation.
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