The use of a topical capsaicin 8%may be effective in neuropathic pain associated with postherpetic neuralgia or resulting from trauma or surgery.
The FDA has granted Fast Track designation to CNTX-4975, a highly potent, ultrapure, synthetic form of trans-capsaicin, for the treatment of pain associated with knee osteoarthritis.
Treatment with the capsaicin 8% patch Qutenza may be more effective than pregabalin for reducing the intensity and area of dynamic mechanical allodynia and for complete resolution of the disorder.
The higher interictal levels of oxytocin observed in patients with chronic migraine compared with unaffected individuals may contribute to the affective component of experimental pain.
The use of capsaicin 8% patch repeat treatment is well tolerated and may provide effective long-term benefit in patients with peripheral neuropathic pain.
The stimulation of the transient receptor potential vanilloid 1 receptor may explain the benefits of capsaicin and hot water hydrotherapy in patients experiencing cannabinoid hyperemesis syndrome.
Results from the ASCEND study recently published in BioMed Central Neurology indicate that an 8% capsaicin patch is effective in relieving peripheral neuropathic pain resulting from a wide range of etiologies.
Limited data suggest antidepressants, topical capsaicin, and fat grafting may reduce pain associated with post-mastectomy pain syndrome, but more and better studies are needed to determine optimal management for this debilitating condition.
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