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BICILLIN C-R 900/300
Bacterial infections
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Drug Name:

BICILLIN C-R 900/300 Rx

Generic Name and Formulations:
Penicillin G benzathine 900,000 units, penicillin G procaine 300,000 units; per syringe; susp for deep IM inj; contains parabens.

Pfizer Inc.

Therapeutic Use:

Indications for BICILLIN C-R 900/300:

Susceptible moderately severe infections including respiratory, skin and soft tissue, erysipelas, scarlet fever, otitis media.


Use other strengths.


Give by deep IM inj into upper, outer buttock or anterolateral thigh; for younger children, midlateral thigh may be preferred. Group A strep: one inj of 900/300 once. Pneumococcal: one inj of 900/300 every 2–3 days until afebrile for 48 hours.

Boxed Warning:

Not for IV use. Do not admix with other IV solutions. Reports of inadvertent IV administration has been associated with cardiorespiratory arrest and death.


Not for IV use; do not inject into or near an artery or nerve. History of cephalosporin or significant allergies. Asthma. Increased risk of methemoglobinemia in G6PD deficiency, congenital/idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6mos; monitor and discontinue if occurs. Monitor renal and hematopoietic function in prolonged use. Discontinue if superinfection develops. Pregnancy. Nursing mothers.

See Also:


Pharmacological Class:

Penicillinase-sensitive penicillin.


Do not admix with other intravenous solutions. Antagonized by concomitant tetracycline; avoid. Potentiated by probenecid. Increased risk of methemoglobinemia with concomitant local anesthetics, acetaminophen, sulfonamides, nitrates, phenytoin, phenobarbital; see full labeling.

Adverse Reactions:

Rash, drug fever, serum sickness, anaphylaxis, blood dyscrasias, neuropathy, nephropathy, inj site reactions, methemoglobinemia, C. difficile-associated diarrhea.

How Supplied:

C-R disposable syringe 600,000 units/mL (2mL)—10 (w. 1 inch or 1.25 inch needles); C-R 900/300 disposable syringe 1.2 million units (2mL)—10 (w. 1 inch needle)

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