Benzodiazepines

Prevalence of Benzodiazepine Use, Misuse Among US Adults Analyzed

Prevalence of Benzodiazepine Use, Misuse Among US Adults Analyzed

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Alprazolam was found to be the most commonly misused benzodiazepine.

Physical, Sexual Abuse and Concurrent Opioid/Benzodiazepine Use in Chronic Pain

Physical, Sexual Abuse and Concurrent Opioid/Benzodiazepine Use in Chronic Pain

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Patients with chronic pain and a history of physical and sexual abuse were found to be more likely to concurrently use benzodiazepine and opioids.

Overdose Risk Highest in First Days of Concurrent Opioid, Benzodiazepine Use

Overdose Risk Highest in First Days of Concurrent Opioid, Benzodiazepine Use

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

Mandatory PDMP for Prescribers Lowers Opioid Dispensing Rate

Mandatory PDMP for Prescribers Lowers Opioid Dispensing Rate

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Legislation that requires prescribers to check Ohio's Prescription Drug Monitoring Program was found to lead to a reduction in the quantity of opioids and benzodiazepines dispensed.

Adults Using Benzodiazepines More Likely to Receive Opioid Prescription

Adults Using Benzodiazepines More Likely to Receive Opioid Prescription

New opioid prescriptions for U.S. adults using benzodiazepines stopped increasing in 2010, although the likelihood of receiving a prescription is still elevated versus the general population.

Minimizing False Negatives in Urine Benzodiazepine Screening

Minimizing False Negatives in Urine Benzodiazepine Screening

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Hydrolysis of urine before benzodiazepine immunoassay screening and optimization of the immunoassay absorbance cutoff were found to improve the rate of false-negative screening.

FDA: Opioid Addiction Medication Should Not Be Withheld While Taking CNS Depressants

FDA: Opioid Addiction Medication Should Not Be Withheld While Taking CNS Depressants

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A review of several published studies showed that the evidence did not support dose limitations or arbitrary caps of buprenorphine or methadone as a strategy to address benzodiazepine or other CNS depressant use in MAT-treated patients.

Midazolam Plus Morphine: Continuous vs Intermittent Infusions for Pediatric Postsurgical Pain

Midazolam Plus Morphine: Continuous vs Intermittent Infusions for Pediatric Postsurgical Pain

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Continuous infusions of midazolam plus morphine do not provide additional pain relief compared with intermittent dosing of those drugs, and may increase hospital length of stay among pediatric patients who have undergone cardiac surgery.

FDA's Strategies for Managing Patients Taking CNS Depressants and Opioids

FDA's Strategies for Managing Patients Taking CNS Depressants and Opioids

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The FDA has recently issued a report advising against the use of buprenorphine and methadone medications in patients taking benzodiazepines and/or other central nervous system depressants.

Benzodiazepine and Opioid Prescribing in the Elderly: What Are the Risks?

Benzodiazepine and Opioid Prescribing in the Elderly: What Are the Risks?

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Dr Gould covered the risks of co-prescribing benzodiazepines and opioids, particularly for elderly patients, and proposed therapeutic alternatives at PAINWeek 2017.

Overdose: Mitigating the Legal Risk

Overdose: Mitigating the Legal Risk

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Jennifer Bolen, JD, provides PAINWeek 2017 attendees with information on risk reduction and response to medication overdose events.

Fracture Risk and Psychotropic Medication Use

Fracture Risk and Psychotropic Medication Use

Mental disorders and psychotropic medication use are associated with an increased risk for fracture but are not fully captured by a tool used to assess fracture risk in the general population.

Clobazam for Low Back Pain

Clobazam for Low Back Pain

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Clobazam is more effective than placebo in reducing low back pain.

Benzodiazepine Use Increases Pneumonia Risk in Alzheimer Disease

Benzodiazepine Use Increases Pneumonia Risk in Alzheimer Disease

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Patients with Alzheimer disease who were receiving benzodiazepines had a risk for pneumonia 30% greater than that of matched control patients.

Opioid/Benzodiazepine Combination Increases Risk of Overdose

Opioid/Benzodiazepine Combination Increases Risk of Overdose

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Concurrent benzodiazepine and opioid use increased by 80% between 2001 and 2013 in the United States and significantly contributes to the overall population risk of opioid overdose.

CDC Guideline on Prescribing Opioids: Some Major Concerns

CDC Guideline on Prescribing Opioids: Some Major Concerns

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Dr Fudin discusses concerns he has regarding the CDC guideline for prescribing opioids for chronic pain.

Sudden-Onset Amnesia Seen With Opioid Abuse

Sudden-Onset Amnesia Seen With Opioid Abuse

Short-term memory loss may be yet another price of America's opioid addiction epidemic.

New Prescribing Information Released for Hundreds of FDA-Approved Opioids

New Prescribing Information Released for Hundreds of FDA-Approved Opioids

Throughout 2016, the FDA has announced requirements for manufacturers to create new product labeling information for a variety of opioid medications.

Are Muscle Relaxants Effective for Treating Low Back Pain?

Are Muscle Relaxants Effective for Treating Low Back Pain?

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Meta-analysis shows muscle relaxants are effective in reducing acute but not chronic low back pain.

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