LAS VEGAS — Abuse-deterrent extended-release oxycodone (Xtampza® ER; Collegium Pharmaceutical) provided adequate pain relief for patients with chronic low back pain who were previously receiving immediate-release oxycodone, according to research presented at PAINWeek 2017, held September 5-9, in Las Vegas, Nevada.1

In a post hoc analysis of a phase 3 efficacy and safety study of the abuse-deterrent oxycodone ER, researchers evaluated the impact of switching from immediate-release oxycodone to extended-release oxycodone over a 12-week period. All participants had chronic low back pain that was poorly managed on an immediate-release oxycodone regimen.

At week 12, patients had significant improvements in average pain intensity from baseline (mean difference [SE]: -1.94 [0.62]; P =.002). The oxycodone extended-release group also had significantly better global impressions of change, a smaller proportion of study drop-out, and different responder analysis compared with placebo (P <.005 for all). Patients receiving oxycodone extended-release also used numerically less rescue medication. Adverse events did not differ between groups in this study.

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In an interview with Clinical Pain Advisor, Diana Meske, PhD, lead author on the study, said that the data “support that some patients on an immediate-release oxycodone regimen can be switched to a dose of Xtampza ER to effectively and safely control their pain.”

Disclosure: Dr Meske reports being employed by Collegium Pharmaceutical.

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  1. Meske D, Place A, Vaughn B. Converting patients with chronic pain from immediate-release oxycodone to Xtampza® ER, an extended-release, abuse-deterrent formulation. Presented at: PAINWeek 2017; September 5-9; Las Vegas, Nevada. Abstract 18.