Wayne L. Chandler, Author at Clinical Pain Advisor

Wayne L. Chandler

All articles by Wayne L. Chandler

Plasminogen Deficiency

At a Glance Plasminogen deficiency is an inherited disorder that, in its severe homozygous form, is associated with compromised extracellular fibrin clearance, abnormal mucous membrane wound healing, and pseudomembranous (ligneous) lesions on affected mucous membranes, particularly the eyes (ligneous conjunctivitis) and mouth (ligneous gingivitis). Ligneous conjunctivitis is characterized by early chronic tearing and redness of…

Antithrombin Deficiency

At a Glance Antithrombin deficiency is an inherited venous thrombotic disorder. A history of unexplained venous thrombosis in a patient less than 50 years of age with a family history of venous thrombosis should prompt consideration of antithrombin deficiency. First, venous thrombosis with antithrombin deficiency typically occurs in otherwise healthy individuals at approximately 30 years…

Protein S Deficiency

At a Glance Protein S deficiency is an inherited venous thrombotic disorder. A history of unexplained venous thrombosis in a patient younger than 50 years of age with a family history of venous thrombosis should prompt consideration of protein S deficiency. First, venous thrombosis with protein S deficiency typically occurs in otherwise healthy individuals at…

Protein C Deficiency

At a Glance Protein C deficiency is an inherited venous thrombotic disorder. A history of unexplained venous thrombosis in a patient younger than 50 years of age with a family history of venous thrombosis should prompt consideration of protein C deficiency. First venous thrombosis with protein C deficiency typically occurs in otherwise healthy individuals at…

Prothrombin 20210 Mutation

At a Glance The prothrombin 20210 mutation is an inherited venous thrombotic disorder. A history of unexplained venous thrombosis in a patient younger than 50 years of age with a family history of venous thrombosis should prompt consideration of the prothrombin 20210 mutation. First, venous thrombosis with heterozygous prothrombin 20210 mutation typically occurs in otherwise…

Factor V Leiden Mutation

At a Glance Factor V Leiden is an inherited venous thrombotic disorder. A history of unexplained venous thrombosis in a patient less than 50 years of age with a family history of venous thrombosis should prompt consideration for factor V Leiden. First, venous thrombosis with heterozygous factor V Leiden typically occurs in otherwise healthy individuals…

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