Mark Thoelke, Author at Clinical Pain Advisor

Mark Thoelke

All articles by Mark Thoelke

Addison's disease (primary adrenocortical insufficiency)

I. What every physician needs to know. Addison’s disease, or primary adrenocortical insufficiency, is characterized by a deficiency in endogenous cortisol production secondary to destruction or dysfunction of the adrenal cortices. In the United States (US), Addison’s disease is most commonly caused by autoimmune destruction (80% of spontaneous cases), but also has infectious, vascular, metastatic,…

Weakness; Focal

Focal weakness I. Problem/Condition. Weakness is among the most common complaints of patients presenting to the clinic and the hospital, Generalized weakness is very nonspecific, with a long list of potential causes. However, pursuing a rigorous history and neurologic exam using a framework for localizing the source of weakness can help to narrow the differential…

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