Challenges in Developing Therapeutics for Addiction and Pain
In light of the rapid increases in opioid overdose deaths, there is an urgent need to develop better treatment options for pain and addiction.
All articles by Amit Akirov, MD
Adrenergic, Not Opioid Pathways, May Mediate Rapid Death From Fentanyl
Fentanyl and fentanyl analogues may cause rapid death through airway compromise and severe muscle rigidity.
Perseverative Thinking May Partially Mediate the Association Between Pain Intensity and Catastrophizing
Perseverative thinking may partially mediate the relationship between pain and catastrophizing.
Fibromyalgia Assessment Screening Tool May Facilitate Diagnosis in Routine Care
Simple Fibromyalgia Assessment Screening Tool indices may facilitate the diagnosis of fibromyalgia in the routine care of patients with other rheumatic diseases.
Patients With Migraine at Increased Risk for Traumatic Brain Injury
Migraine is a potential risk factor for the development of traumatic brain injury (TBI) and is associated with a 78% increased risk for TBI compared with individuals without migraine.
Novel Opioid Receptor Agonist Found Effective for Chronic Low Back Pain
NKTR-181 was found to be a safe, effective, and well tolerated treatment over the long term in patients with moderate to severe chronic low back pain.
Pressure Pain Hypersensitivity Not Restricted to MSK Structures in Episodic Tension-Type Headache
Women with frequent episodic tension-type headache may have widespread pressure pain hypersensitivity in musculoskeletal structures and over nerve trunks.
Asymptomatic Idiopathic Intracranial Hypertension: Is It a Precursor to Symptomatic Disease in Children?
Less pronounced clinical and radiologic features in asymptomatic idiopathic intracranial hypertension (IIH) may serve as early indicators for symptomatic IIH in children.
Effects of Aquatic Physiotherapy vs Health Education for Fibromyalgia
Aquatic physiotherapy may not be superior to a health education program in treating women with fibromyalgia.
ACT-Based Interdisciplinary Rehabilitation Program Effective for Chronic Pain
A ten-week outpatient Acceptance and Commitment Therapy (ACT)-based interdisciplinary pain rehabilitation program for individuals with chronic pain was associated with improvements that included pain severity, pain interference, and physical and mental health-related quality of life.
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