Vitamin D May Not Benefit Knee Osteoarthritis

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Supplements didn't slow disease progression or ease pain, even in patients with low levels of vitamin D.
Supplements didn't slow disease progression or ease pain, even in patients with low levels of vitamin D.

HealthDay News — Vitamin D supplements don't appear to relieve pain or slow the progression of knee osteoarthritis in patients with low levels of the vitamin, according to a study published in the March 8 issue of the Journal of the American Medical Association.

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Changhai Ding, MD, PhD, a professor at the University of Tasmania in Hobart, and colleagues randomly assigned 413 patients with knee osteoarthritis and low vitamin D levels to monthly treatment with either 50 000 International Units of vitamin D a month or a placebo.

 

Over 2 years of follow-up, the investigators did not see any difference between the groups in reduced pain, change in tibiofemoral cartilage defects, or change in tibiofemoral bone marrow lesions.

"These data suggest a lack of evidence to support vitamin D supplementation for slowing disease progression or structural change in knee osteoarthritis," Ding told HealthDay.

Reference

Jin X, Jones G, Cicuttini F, et al. Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2016; doi:10.1001/jama.2016.1961.

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