Vitamin D May Not Benefit Knee Osteoarthritis
Supplements didn't slow disease progression or ease pain, even in patients with low levels of vitamin D.
HealthDay News — Vitamin D supplements don't appear to relieve pain or slow the progression of knee osteoarthritis in patients with low levels of the vitamin, according to a study published in the March 8 issue of the Journal of the American Medical Association.
Changhai Ding, MD, PhD, a professor at the University of Tasmania in Hobart, and colleagues randomly assigned 413 patients with knee osteoarthritis and low vitamin D levels to monthly treatment with either 50 000 International Units of vitamin D a month or a placebo.
Over 2 years of follow-up, the investigators did not see any difference between the groups in reduced pain, change in tibiofemoral cartilage defects, or change in tibiofemoral bone marrow lesions.
"These data suggest a lack of evidence to support vitamin D supplementation for slowing disease progression or structural change in knee osteoarthritis," Ding told HealthDay.
Jin X, Jones G, Cicuttini F, et al. Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2016; doi:10.1001/jama.2016.1961.