Allodynia

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

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Cotargeting of peripheral μ-opioid and cannabinoid receptors was found to have a synergistic effect in reducing mechanical allodynia in a mouse model of neuropathic pain.

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

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Treatment with the capsaicin 8% patch Qutenza may be more effective than pregabalin for reducing the intensity and area of dynamic mechanical allodynia and for complete resolution of the disorder.

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

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Chronic pain experienced by patients with pachyonychia congenita may be caused by damage to the peripheral nerve fibers, with the hyperalgesia and allodynia observed in affected regions likely to be manifestations of peripheral sensitization.

Elevated Interictal Oxytocin Associated With Affective Pain in Chronic Migraine

Elevated Interictal Oxytocin Associated With Affective Pain in Chronic Migraine

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The higher interictal levels of oxytocin observed in patients with chronic migraine compared with unaffected individuals may contribute to the affective component of experimental pain.

Identification of Mechanism Involved in the Maintenance of Pain Behaviors, Mechanical Hypersensitivity

Identification of Mechanism Involved in the Maintenance of Pain Behaviors, Mechanical Hypersensitivity

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The extracellular phosphorylation of EphB2 was shown to maintain pain behaviors and mechanical hypersensitivity after injury.

Allodynia and Pericranial Tenderness Highly Prevalent in Pediatric Patients With Migraine

Allodynia and Pericranial Tenderness Highly Prevalent in Pediatric Patients With Migraine

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Symptoms associated with central sensitization are common in children and adolescents with migraine.

Impact of Allodynia on Acute Migraine Treatment

Impact of Allodynia on Acute Migraine Treatment

The understanding of the mechanisms of allodynia is essential for the treatment of migraine.

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