Generic Name and Formulations:
Dipyridamole 200mg (extended-release), aspirin 25mg (immediate-release); caps.
Boehringer Ingelheim Pharmaceuticals
Indications for AGGRENOX:
To reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis.
Swallow whole. 1 cap twice daily, one in the morning and one in the evening. Alternative regimen in case of intolerable headaches: switch to 1 cap at bedtime and low-dose aspirin in AM; return to usual regimen as soon as possible, usually within 1 week.
NSAID allergy. Patients with the syndrome of asthma, rhinitis, and nasal polyps. Viral infection in children/teens (risk of Reye syndrome).
Not interchangeable with individual components of aspirin and dipyridamole. Increased risk of bleeding, including GI bleed. History of active peptic ulcer, severe hepatic or renal dysfunction; avoid. Coronary artery disease. Pre-existing hypotension. Chronic, heavy alcohol use. Pregnancy (Cat.D); avoid during 3rd trimester and during labor & delivery. Nursing mothers.
Increased risk of bleeding with anticoagulants, antiplatelets, heparin, anagrelide, fibrinolytic therapy, alcohol, chronic NSAID use. Potentiates adenosine, acetazolamide, methotrexate, oral hypoglycemics. May antagonize ACE inhibitors, β-blockers, diuretics, cholinesterase inhibitors, uricosurics. May increase risk of renal dysfunction with NSAIDs. Monitor phenytoin, valproic acid, other anticonvulsants.
Headache, dyspepsia, abdominal pain, nausea, diarrhea; bleeding risk, increased liver enzymes, hepatic failure.
Hepatic. 99% protein bound.
Clinical Pain Advisor Articles
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Reducing Mortality After Overdose: Is Treatment for Opioid Use Disorder Effective?
- A Physician's Guide to Incorporating Patient Spirituality in Practice
- Low Literacy Self-Management Program for Chronic Pain May Be Effective
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- The Challenge of Compassion in Modern Healthcare Settings
- Republican Opposition to Obamacare: What's Done, What's to Come
- Lowering Default Pill Counts in EMRs May Effectively Reduce Postoperative Opioid Prescription Numbers
- Steps Taken to Increase Use of Electronic Tools in Medicine
- Daily and Retrospective Pain Measurements Comparable in Hip Osteoarthritis