Generic Name and Formulations:
Tirofiban (as HCl monohydrate) 50mcg/mL; per bag or vial; soln for IV infusion; 250mcg/mL; per vial; soln for IV bolus.
Medicure Pharma, Inc.
Indications for AGGRASTAT:
To reduce the rate of thrombotic cardiovascular events (combined endpoint of death, MI, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndrome.
May give bolus dose via a syringe or IV pump. Administer 25mcg/kg intravenously within 5mins and then 0.15mcg/kg/min via IV infusion pump for up to 18hrs. Renal impairment (CrCl ≤60mL/min): 25mcg/kg intravenously within 5mins and then 0.075mcg/kg/min for up to 18hrs.
Within previous 30 days: active internal bleeding, bleeding diathesis, major surgery, or severe physical trauma. History of thrombocytopenia after previous tirofiban therapy.
Monitor platelet counts 6hrs after initiation and daily thereafter. If platelet decreases to <90,000/mm3, monitor to exclude pseudothrombocytopenia. Discontinue tirofiban (and heparin) if thrombocytopenia confirmed. Previous exposure to a GP IIb/IIIa blocker may increase risk of thrombocytopenia. Minimize other arterial and venous punctures, IM injections, catheter use, nasotracheal intubation to lower bleeding risk. Severe renal insufficiency. Hemodialysis. Pregnancy (Cat.B). Nursing mothers: not recommended.
Increased risk of bleeding with concomitant fibrinolytics, anticoagulants, antiplatelets.
Bleeding (may be fatal), pelvic pain, bradycardia, coronary artery dissection; thrombocytopenia, anaphylaxis.
Premixed bag (100mL, 250mL)—1; Premixed vial (100mL)—1; Premixed bolus vial (15mL)—1
Clinical Pain Advisor Articles
- Notifications by PDMPs May Not Effectively Reduce Opioid Misuse
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Electroacupuncture May Help Reduce Opioid Use in Chronic Musculoskeletal Pain
- Low Literacy Self-Management Program for Chronic Pain May Be Effective
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- The Challenge of Compassion in Modern Healthcare Settings
- Republican Opposition to Obamacare: What's Done, What's to Come
- Lowering Default Pill Counts in EMRs May Effectively Reduce Postoperative Opioid Prescription Numbers
- Steps Taken to Increase Use of Electronic Tools in Medicine
- Daily and Retrospective Pain Measurements Comparable in Hip Osteoarthritis