Acute Pain

FDA Panel Votes on Drug/Device Combo to Treat Pain in Medically Supervised Setting

FDA Panel Votes on Drug/Device Combo to Treat Pain in Medically Supervised Setting

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The FDA is not bound by the Committee's recommendation but takes it into consideration when making its decision.

FDA Committee Votes on First-of-Its-Kind Pain Drug Oliceridine

FDA Committee Votes on First-of-Its-Kind Pain Drug Oliceridine

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Oliceridine, a G-protein biased mu-opioid receptor (MOR) ligand, has a unique mechanism of action that allows for more selective pathway activation while avoiding a pathway associated with opioid-related adverse events.

Incorrect Dosing Information Prompts Recall of Robaxin 750mg Tablets

Incorrect Dosing Information Prompts Recall of Robaxin 750mg Tablets

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Robaxin is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

Vibrating Kinetic Anesthesia Device May Reduce Pain Associated With Lidocaine Injections

Vibrating Kinetic Anesthesia Device May Reduce Pain Associated With Lidocaine Injections

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The use of a vibrating kinetic anesthesia device may be well-tolerated and effective in reducing pain associated with infiltrative lidocaine injections for biopsy and excisional surgery.

IV Hydromorphone vs IV Acetaminophen for Severe Acute Pain in the ED

IV Hydromorphone vs IV Acetaminophen for Severe Acute Pain in the ED

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Intravenous hydromorphone may provide greater analgesic effect compared with intravenous acetaminophen in adult patients presenting to the emergency department with severe acute pain.

Pregabalin May Not Improve Analgesia During Medical Abortion

Pregabalin May Not Improve Analgesia During Medical Abortion

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Pregabalin co-administered with misoprostol was not found to reduce pain intensity in women initiating medical abortion, but was found to be associated with increased satisfaction and reduced use of narcotics and ibuprofen.

Pain Scores After Total Knee Arthroplasty May Predict Chronic Opioid Use

Pain Scores After Total Knee Arthroplasty May Predict Chronic Opioid Use

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Acute postoperative pain scores were found to be associated with chronic opioid use after total knee arthroplasty in patients taking opioid medications prior to intervention.

Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor

Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor

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Virtual reality may effectively alleviate pain and anxiety for unmedicated women experiencing contractions during the first stage of labor.

Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain

Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain

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Consensus guidelines regarding the use of ketamine for the management of acute pain have been approved.

Antipyretic Medications

Information on fever-reducing medications including formulation, strength and dosage.

Acute Pain Treatment in the ED: Consensus Guidelines

Acute Pain Treatment in the ED: Consensus Guidelines

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A panel of emergency medicine and pharmacology experts formulated guidelines for safely and effectively treating patients presenting to the emergency department with acute pain.

Custom Foot Orthotics vs OTC Insoles for Plantar Heel Pain

Custom Foot Orthotics vs OTC Insoles for Plantar Heel Pain

Researchers conducted a systematic literature review to identify randomized controlled trials comparing 8 different types of foot orthotics.

Non-Opioid Therapies for Pain Management in the ED

Non-Opioid Therapies for Pain Management in the ED

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The use of non-opioid analgesic therapies is increasing among ED physicians.

Phrenic Nerve Infiltration vs SNB for Acute Ipsilateral Shoulder Pain

Phrenic Nerve Infiltration vs SNB for Acute Ipsilateral Shoulder Pain

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Investigators sought to determine whether phrenic nerve infiltration and suprascapular nerve block would control acute ipsilateral shoulder pain after thoracotomy.

Benzhydrocodone/Acetaminophen Combination Gets FDA Approval for Severe Acute Pain

Benzhydrocodone/Acetaminophen Combination Gets FDA Approval for Severe Acute Pain

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The FDA has approved Apadaz for the short-term management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Predicting Acute Pain After Cesarean Delivery to Reduce Risk for Persistent Pain

Predicting Acute Pain After Cesarean Delivery to Reduce Risk for Persistent Pain

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The most promising tools to predict acute pain after cesarean delivery are local anesthetic infiltration before placement of spinal anesthesia, and asking patients simple questions about anticipated pain and analgesic needs.

High Bioavailability, Fast Absorption of Buprenorphine With New Sublingual Wafer

High Bioavailability, Fast Absorption of Buprenorphine With New Sublingual Wafer

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Preliminary results suggest that a new sublingual buprenorphine wafer may offer high bioavailability and fast absorption for patients treated for acute and chronic pain.

Low-Dose Ketamine Provides Comparable Acute Pain Relief, More Adverse Events Than Morphine

Low-Dose Ketamine Provides Comparable Acute Pain Relief, More Adverse Events Than Morphine

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Acute pain management in the emergency department with low-dose ketamine may provide pain relief comparable with morphine at 30 minutes.

ACTTION Consensus Provides Best Practices for the Design of Pediatric Clinical Trials Focused on Acute Pain

ACTTION Consensus Provides Best Practices for the Design of Pediatric Clinical Trials Focused on Acute Pain

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Key factors susceptible to improve the design of clinical trials on analgesics for acute pain in pediatric populations were reviewed and recommendations published.

High Prevalence of Musculoskeletal Disorders in At-Risk Physicians

High Prevalence of Musculoskeletal Disorders in At-Risk Physicians

The most common work-related musculoskeletal disorders in physicians were found to be degenerative cervical spine disease, rotator cuff pathology, degenerative lumbar spine disease, and carpal tunnel syndrome.

FDA Accepts New Drug Application for Novel Buprenorphine Sublingual Spray

FDA Accepts New Drug Application for Novel Buprenorphine Sublingual Spray

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Compared to other commonly used opioids, buprenorphine offers a ceiling effect for respiratory depression and less abuse potential, less cognitive impairment, and less constipation.

Nonopioid Analgesic Combination and Opioid Combinations Provide Similar Analgesic Effects for Acute Extremity Pain

Nonopioid Analgesic Combination and Opioid Combinations Provide Similar Analgesic Effects for Acute Extremity Pain

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Nonopioid analgesic combinations may be noninferior to opioid/acetaminophen combinations for reducing acute extremity pain.

New Drug Application Submitted for Olinvo to Treat Acute Pain

New Drug Application Submitted for Olinvo to Treat Acute Pain

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Trevena has submitted their New Drug Application to the FDA for Olinvo, an oliceridine injection, for the management of moderate-to-severe pain in the hospital and similar settings.

Predictors of Nausea, Vomiting in Patients Receiving Postoperative Opioids

Predictors of Nausea, Vomiting in Patients Receiving Postoperative Opioids

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Opioid treatment of acute postoperative pain was shown to cause high rates of postoperative nausea and vomiting, particularly in women and younger patients.

Acute Pain Management in the Emergency Department With SoluMatrix Indomethacin

Acute Pain Management in the Emergency Department With SoluMatrix Indomethacin

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SoluMatrix indomethacin may represent a treatment option for the management of moderate acute pain, including patients in emergency room settings.

Strategies to Prevent the Transition From Postoperative Acute Pain to Chronic Pain

Strategies to Prevent the Transition From Postoperative Acute Pain to Chronic Pain

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A number of shortcomings are associated with systematic reviews and meta-analyses of postoperative care.

AAOS: Few Hip Fracture Patients Consistently Take Vitamin D

AAOS: Few Hip Fracture Patients Consistently Take Vitamin D

There was a correlation for consistent vitamin D supplementation with increase in physical component of the SF-12 score.

Online Tool To Determine When Tests Are Needed for Chest Pain

Online Tool To Determine When Tests Are Needed for Chest Pain

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An online tool predicts which patients with chest pain are likely to have normal non-invasive test results and remain free of cardiac adverse events.

Lidocaine Safe, Effective for Pain in the ICU

Lidocaine Safe, Effective for Pain in the ICU

Intravenous lidocaine seems safe for reducing pain among patients in the intensive care unit with varying degrees of organ dysfunction.

Opioids vs NSAIDs Following Motor Vehicle Collision

Opioids vs NSAIDs Following Motor Vehicle Collision

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Opioids prescribed for pain following a motor vehicle collision do not reduce the likelihood of developing persistent pain.

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