Acute Pain

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Clinicians on Sufentanil Sublingual Tablet Safety Study

Clinicians on Sufentanil Sublingual Tablet Safety Study

The pooled analysis (N=804) evaluated clinical studies of sufentanil sublingual tablet (SST) at 30mcg dose equivalents over ≤72 hours for moderate-to-severe acute pain management in both postoperative and emergency room patients.

FDA Approves Two New Strengths of Apadaz for Pain Management

FDA Approves Two New Strengths of Apadaz for Pain Management

Apadaz was initially approved in February 2018 as 6.12mg/325mg immediate-release tablets for the short-term (no more than 14 days) management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Treatments Appear No Better Than Placebo for Tennis Elbow

Treatments Appear No Better Than Placebo for Tennis Elbow

At best, all treatments provide only small pain relief for tennis elbow.

Postpartum Pain Associated With Increased Risk for Postpartum Depression

Postpartum Pain Associated With Increased Risk for Postpartum Depression

Patients at high risk for postpartum depression may need denser analgesia control after delivery.

Women Fed Soy Formula as Infants More Likely to Experience Menstrual Pain

Women Fed Soy Formula as Infants More Likely to Experience Menstrual Pain

Researchers at the National Institute of Environmental Health Sciences (NIEHS), Vanderbilt University Medical Center, and the Henry Ford Health System analyzed patient data from African-American women aged 23 to 35 years (N=1553) who were participating in the NIEHS Study of Environment, Lifestyle, and Fibroids (SELF).

Dsuvia Approved for Management of Acute Pain in Healthcare Settings

Dsuvia Approved for Management of Acute Pain in Healthcare Settings

The sublingual formulation of sufentanil offers a new treatment option for patients with nothing by mouth (NPO) status and patients with difficult IV access.

FDA Panel Votes on Drug/Device Combo to Treat Pain in Medically Supervised Setting

FDA Panel Votes on Drug/Device Combo to Treat Pain in Medically Supervised Setting

The FDA is not bound by the Committee's recommendation but takes it into consideration when making its decision.

FDA Committee Votes on First-of-Its-Kind Pain Drug Oliceridine

FDA Committee Votes on First-of-Its-Kind Pain Drug Oliceridine

Oliceridine, a G-protein biased mu-opioid receptor (MOR) ligand, has a unique mechanism of action that allows for more selective pathway activation while avoiding a pathway associated with opioid-related adverse events.

Incorrect Dosing Information Prompts Recall of Robaxin 750mg Tablets

Incorrect Dosing Information Prompts Recall of Robaxin 750mg Tablets

Robaxin is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

Vibrating Kinetic Anesthesia Device May Reduce Pain Associated With Lidocaine Injections

Vibrating Kinetic Anesthesia Device May Reduce Pain Associated With Lidocaine Injections

The use of a vibrating kinetic anesthesia device may be well-tolerated and effective in reducing pain associated with infiltrative lidocaine injections for biopsy and excisional surgery.

IV Hydromorphone vs IV Acetaminophen for Severe Acute Pain in the ED

IV Hydromorphone vs IV Acetaminophen for Severe Acute Pain in the ED

Intravenous hydromorphone may provide greater analgesic effect compared with intravenous acetaminophen in adult patients presenting to the emergency department with severe acute pain.

Pregabalin May Not Improve Analgesia During Medical Abortion

Pregabalin May Not Improve Analgesia During Medical Abortion

Pregabalin co-administered with misoprostol was not found to reduce pain intensity in women initiating medical abortion, but was found to be associated with increased satisfaction and reduced use of narcotics and ibuprofen.

Pain Scores After Total Knee Arthroplasty May Predict Chronic Opioid Use

Pain Scores After Total Knee Arthroplasty May Predict Chronic Opioid Use

Acute postoperative pain scores were found to be associated with chronic opioid use after total knee arthroplasty in patients taking opioid medications prior to intervention.

Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor

Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor

Virtual reality may effectively alleviate pain and anxiety for unmedicated women experiencing contractions during the first stage of labor.

Opioids for Obstructive Sleep Apnea Should Be Used With Caution

Opioids for Obstructive Sleep Apnea Should Be Used With Caution

Current literature suggests that opioids should be used with caution in individuals with obstructive sleep apnea in order to prevent opioid-induced respiratory depression.

Parenteral Opioids May Be Effective for Reducing Pain During Childbirth According to Cochrane Review

Parenteral Opioids May Be Effective for Reducing Pain During Childbirth According to Cochrane Review

The use of parenteral opioid medications may be supported for effective pain relief during labor.

Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain

Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain

Consensus guidelines regarding the use of ketamine for the management of acute pain have been approved.

Antipyretic Medications

Information on fever-reducing medications including formulation, strength and dosage.

Recommendations Developed for Managing Postpartum Pain

Recommendations Developed for Managing Postpartum Pain

Noting that untreated pain is associated with increased risks of greater opioid use, postpartum depression, and development of persistent pain, the authors recommend non-pharmacologic and pharmacologic therapies as components of postpartum pain management.

Gluteal Loading Exercise May Not Improve Greater Trochanteric Pain Syndrome

Gluteal Loading Exercise May Not Improve Greater Trochanteric Pain Syndrome

Adding an exercise regimen to a comprehensive educational program for the management of greater trochanteric pain syndrome may not bring significant benefit.

Simple Trick May Reduce Procedural Pain

Simple Trick May Reduce Procedural Pain

Dripping lidocaine onto the skin prior to lidocaine injection may help reduce injection-associated procedural pain.

Acute Pain Treatment in the ED: Consensus Guidelines

Acute Pain Treatment in the ED: Consensus Guidelines

A panel of emergency medicine and pharmacology experts formulated guidelines for safely and effectively treating patients presenting to the emergency department with acute pain.

Custom Foot Orthotics vs OTC Insoles for Plantar Heel Pain

Custom Foot Orthotics vs OTC Insoles for Plantar Heel Pain

Researchers conducted a systematic literature review to identify randomized controlled trials comparing 8 different types of foot orthotics.

Virtual Reality as a Distraction From Pain During Medical Procedures

Virtual Reality as a Distraction From Pain During Medical Procedures

Virtual reality appears to be an effective distraction intervention to relieve pain and distress during various medical procedures.

Non-Opioid Therapies for Pain Management in the ED

Non-Opioid Therapies for Pain Management in the ED

The use of non-opioid analgesic therapies is increasing among ED physicians.

Phrenic Nerve Infiltration vs SNB for Acute Ipsilateral Shoulder Pain

Phrenic Nerve Infiltration vs SNB for Acute Ipsilateral Shoulder Pain

Investigators sought to determine whether phrenic nerve infiltration and suprascapular nerve block would control acute ipsilateral shoulder pain after thoracotomy.

Benzhydrocodone/Acetaminophen Combination Gets FDA Approval for Severe Acute Pain

Benzhydrocodone/Acetaminophen Combination Gets FDA Approval for Severe Acute Pain

The FDA has approved Apadaz for the short-term management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Predicting Acute Pain After Cesarean Delivery to Reduce Risk for Persistent Pain

Predicting Acute Pain After Cesarean Delivery to Reduce Risk for Persistent Pain

The most promising tools to predict acute pain after cesarean delivery are local anesthetic infiltration before placement of spinal anesthesia, and asking patients simple questions about anticipated pain and analgesic needs.

High Bioavailability, Fast Absorption of Buprenorphine With New Sublingual Wafer

High Bioavailability, Fast Absorption of Buprenorphine With New Sublingual Wafer

Preliminary results suggest that a new sublingual buprenorphine wafer may offer high bioavailability and fast absorption for patients treated for acute and chronic pain.

Low-Dose Ketamine Provides Comparable Acute Pain Relief, More Adverse Events Than Morphine

Low-Dose Ketamine Provides Comparable Acute Pain Relief, More Adverse Events Than Morphine

Acute pain management in the emergency department with low-dose ketamine may provide pain relief comparable with morphine at 30 minutes.