Acetaminophen in combination with ibuprofen or oxycodone, as well as diclofenac, and flurbiprofen may offer more effective analgesia for acute postoperative dental pain in adults.
Postoperative pain management that combines a reduction of opioids with the use of intravenous acetaminophen may shorten hospital length of stay, reduce the rate of complications related to opioids, and lower related costs.
The FDA has approved Apadaz for the short-term management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
Intravenous acetaminophen with or without ketorolac is associated with reduced opioid consumption and cost of care after scoliosis surgery in adolescents.
Intravenous Acetaminophen May Reduce Hospital Length of Stay in Adolescents Undergoing Posterior Spinal FusionJanuary 16, 2018
Postoperative management of adolescents undergoing posterior spinal fusion surgery with intravenous acetaminophen may have an opioid-sparing effect, due to a reduced hospital length of stay.
Nonopioid Analgesic Combination and Opioid Combinations Provide Similar Analgesic Effects for Acute Extremity PainDecember 04, 2017
Nonopioid analgesic combinations may be noninferior to opioid/acetaminophen combinations for reducing acute extremity pain.
Acetaminophen-Diclofenac Combination Similar to Acetaminophen Monotherapy for Musculoskeletal Pain ReliefNovember 02, 2017
Acetaminophen plus diclofenac and diclofenac monotherapy are comparable to acetaminophen alone for pain relief in patients with acute blunt minor musculoskeletal extremity trauma.
A significant reduction in the incidence and severity of headaches associated with electroconvulsive therapy (ECT) was observed in patients receiving preemptive analgesia with acetaminophen.
Acetaminophen and ibuprofen are frequently under-dosed in children in the emergency department.
Physicians who want to prescribe alternatives for pain management should familiarize themselves with current research.
Children exposed to acetaminophen prenatally are at increased risk of multiple behavioral difficulties.
CPA reports on a new analgesic formulation designed to provide both immediate and prolonged analgesia for up to 12 hours in patients with acute pain.
Clinical Pain Advisor Articles
- FDA Takes Steps to Reconcile Needs of Patients With Chronic Pain, Efforts to Curb Opioid Epidemic
- DFN-02 Nasal Spray Safe, Effective for Acute Treatment of Episodic Migraine
- Stat Consult: Chronic Low Back Pain
- Opioid Misuse May Help Predict Alcohol Dependence Treatment Outcomes
- Neuropathic Symptoms Worsen Quality of Life, Function in Hip, Knee Osteoarthritis
- Consensus Guidelines for the Use of Intravenous Ketamine for Chronic Pain
- Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain
- Labor Epidural Analgesia Linked to Reduced Likelihood of Successful Breastfeeding
- Switching From Buprenorphine-Naltrexone to XR-Naltrexone as Effective as XR-Naltrexone
- Treatment for Opioid Use Disorder Associated With Reduced Risk for Opioid-Related Deaths
- History of Migraine May Be Associated With Higher Risk for Cochlear Disorders
- Symptom Severity, Sensory Sensitivity May Indicate Pain Centralization in Chronic Overlapping Pain Conditions
- Human Diagnosis Project Aims to Address Challenges Among Uninsured
- Healthcare Technology Affects Younger Patient Satisfaction
- FDA Announces New Drug Shortages Task Force