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Zidovudine Tablets
Viral infections
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Drug Name:

Zidovudine Tablets Rx

Generic Name and Formulations:
Zidovudine 300mg.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Zidovudine Tablets:

HIV infection. Prevention of maternal-fetal HIV transmission.

Adult:

≥18yrs: 600mg daily in divided doses. End-stage renal disease on dialysis: 100mg every 6–8 hours. Vertical transmission, severe anemia and/or neutropenia: see full labeling.

Children:

<6 weeks and/or for vertical transmission: see full labeling. 6 weeks to <18yrs: (4 to <9kg): 24mg/kg/day (12mg/kg twice daily or 8mg/kg 3 times daily); (≥9 to <30kg): 18mg/kg/day (9mg/kg twice daily or 6mg/kg 3 times daily); (≥30kg): 600mg/day (300mg twice daily or 200mg 3 times daily). Alternative dosing based on BSA: 480mg/m2/day (240mg/m2 twice daily or 160mg/m2 3 times daily).

Warnings/Precautions:

Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Monitor for hematologic toxicity; reduce dose or suspend if significant anemia and/or granulocytopenia occurs; transfuse if necessary. Renal or hepatic dysfunction: consider reducing dose. Bone marrow suppression. Risk of liver disease. Women, obesity, prolonged nucleoside exposure, or advanced HIV disease: increased risk of toxicity. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid stavudine, doxorubicin, ribavirin, other nucleoside analogues, other forms of zidovudine. Caution with other cytotoxic or myelosuppressive drugs (eg, ganciclovir, interferon-alpha, ribavirin). Fluconazole, atovaquone, lamivudine, probenecid, valproic acid, methadone increase zidovudine levels. Monitor phenytoin. May be antagonized by rifampin, ritonavir, nelfinavir. Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.

See Also:

RETROVIR CAPSULES

RETROVIR SYRUP

RETROVIR IV

Pharmacological Class:

Nucleoside analogue (reverse transcriptase inhibitor).

Adverse Reactions:

Anemia, neutropenia, headache, malaise, GI disturbances, insomnia, pain, myopathy, neuropathy, myositis, thrombocytopenia, lactic acidosis, steatosis, hepatomegaly, fat redistribution, immune reconstitution syndrome, pancreatitis, others. Children: also fever, cough.

Note:

Register pregnant patients exposed to zidovudine by calling (800) 258-4263. Formerly known under the brand name Retrovir.

Generic Availability:

YES

How Supplied:

Tabs—contact supplier; Caps—100; Syrup—240mL; IV (20mL/vial)—10

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