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XYLOCAINE WITH EPINEPHRINE INJECTION
Anesthetics
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Drug Name:

XYLOCAINE WITH EPINEPHRINE INJECTION Rx

Generic Name and Formulations:
Lidocaine HCl 5mg/mL with epinephrine 1:200000, 10mg/mL with epinephrine 1:100000, 20mg/mL with epinephrine 1:100000; soln; contains methylparaben, sodium metabisulfite.

Company:
Fresenius Kabi USA

Therapeutic Use:

Indications for XYLOCAINE WITH EPINEPHRINE INJECTION:

Local or regional anesthesia for infiltration and nerve block (see literature).

Adult:

See literature for recommended doses based on procedures. When larger volumes are required, only solutions containing epinephrine should be used except where vasopressors are contraindicated. Caudal and lumbar epidural block: administer test dose; epinephrine may serve as a warning of unintentional intravascular inj. For all procedures: max dose: 7mg/kg, not to exceed 500mg. Elderly, debilitated, cardiac and/or liver disease: reduce dose.

Children:

Max dose determined by age and weight. See literature for specific dosages based on procedures.

Warnings/Precautions:

To be administered under the supervision of experienced clinicians. Have intubation, artificial respiration, oxygen therapy and reversal agents available. Intra-articular infusions: not recommended. Avoid intravascular inj. Avoid methylparaben with spinal or epidural anesthesia. Monitor cardiovascular and respiratory vital signs. Severe shock. Heart block. Neurological disease. Spinal deformities. Septicemia. Severe hypertension. Peripheral or hypertensive vascular disease. Hepatic disease. Impaired cardiovascular function. Malignant hyperthermia. Head and neck administration. Labor & delivery: see literature. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Concurrent during or after potent general anesthetic agents may cause cardiac arrhythmias; use caution. Concurrent vasopressor and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents. Severe prolonged hypertension with MAOIs or tricyclic antidepressants. Phenothiazines and butyrophenones antagonize pressor effect of epinephrine; avoid.

See Also:

XYLOCAINE MPF WITH EPINEPHRINE INJECTION

Pharmacological Class:

Local anesthetic + vasoconstrictor.

Adverse Reactions:

CNS effects (eg, lightheadedness, confusion), cardiovascular effects (eg, bradycardia, hypotension, cardiovascular collpase), hypersensitivity reactions, headache, backache, nausea, increased creatinine phosphokinase.

How Supplied:

Multi-dose vial (10mL)—1, 5
Multi-dose vial (20mL, 50 mL)—1
MPF ampules (5mL)—10
MPF ampules (20mL, 30mL)—5
MPF single-dose vial (10mL)—5
MPF single-dose vial (20mL, 30mL)—1
MPF Sterile Pack SD Vial (20mL, 30mL)—5

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