Generic Name and Formulations:
Trimethoprim 100mg, 200mg; tabs.
Various generic manufacturers
Indications for Trimethoprim:
Treatment of initial episodes of uncomplicated UTI due to susceptible strains (E. coli, P. mirabilis, K. pneumoniae, Enterobacter species, coagulase-negative Staphylococcus species, including S. saprophyticus).
Treat for 10 days. 100mg every 12 hours or 200mg every 24 hours. CrCl 15–30mL/min: 50mg every 12 hours. CrCl<15mL/min: not recommended.
Megaloblastic anemia due to folate deficiency.
May interfere with hematopoieses (esp. when given in large doses and/or prolonged periods). Obtain CBCs if signs of serious blood disorder develop, discontinue if significant reduction in any formed blood element is found. Possible folate deficiency. Renal or hepatic impairment. Pregnancy (Cat.C). Nursing mothers.
May potentiate phenytoin. May interfere with serum methotrexate assay, Jaffe alkaline picrate reaction assay for creatinine.
Folic acid inhibitor.
Rash, pruritus, GI upset, blood dyscrasias, hyperkalemia, hyponatremia, fever, increased BUN, serum creatinine; rare: aseptic meningitis, cholestatic jaundice, hypersensitivity reactions.
Clinical Pain Advisor Articles
- Brain Plasticity in Patients With Complex Regional Pain Syndrome
- Chronic Pain Associated With Traumatic Brain Injury: Causes and Management
- Perturbation-Based Rehabilitation Effective for Chronic Low Back Pain
- Migraine Frequency Correlated With Depression and Anxiety
- IBS-Associated Chronic Pain: Formulation of Core Diagnostic Criteria
- Cannabis Use Associated With Aberrant Drug Behaviors
- Walgreens to Carry Naloxone in All Pharmacies to Combat Drug Abuse
- Independent Pharmacies Expanding Services Available to Patients
- Ketamine Exhibits Effective Pain Relief for Refractory Headaches
- Pain In Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach
- Naproxen Plus Muscle Relaxants vs Naproxen Monotherapy for Low Back Pain
- Pain Processing: Examining the Role of Oxytocin
- Short- vs Long-Acting Opioids for Osteoarthritis Pain
- Extended-Release Naltrexone Injections Reduce Opioid Dependence
- Depressive Symptoms in Medical Interns Increased With Work-Family Conflicts