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Timolol maleate
CHF and arrhythmias
Hypertension
Migraine and headache
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Drug Name:

Timolol maleate Rx

Generic Name and Formulations:
Timolol maleate 5mg, 10mg+, 20mg+; tabs; +scored.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Timolol maleate:

In stabilized patients after MI, to reduce mortality and risk of reinfarction.

Adult:

10mg twice daily.

Children:

Not recommended.

Contraindications:

Asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Cerebrovascular insufficiency. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hypotension, bradycardia with catecholamine-depleting drugs. May increase cardiac effects of calcium channel blockers, digitalis. May be potentiated by quinidine. Increased rebound hypertension with clonidine withdrawal. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine.

Pharmacological Class:

Beta-blocker.

Adverse Reactions:

Cardiac failure, bronchospasm, asthenia, bradycardia, dizziness, arrhythmia, heart block, dyspnea, muscle weakness, cold extremities, decreased libido, chest pain, syncope, pruritus.

Note:

Formerly known under the brand name Blocadren.

How Supplied:

Contact supplier.

Indications for Timolol maleate:

Hypertension.

Adult:

Initially 10mg twice a day. Increase weekly if needed. Usual maintenance: 20–40mg/day; max 60mg/day in 2 divided doses.

Children:

Not recommended.

Contraindications:

Asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Cerebrovascular insufficiency. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hypotension, bradycardia with catecholamine-depleting drugs. May increase cardiac effects of calcium channel blockers, digitalis. May be potentiated by quinidine. Increased rebound hypertension with clonidine withdrawal. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine.

Pharmacological Class:

Beta-blocker.

Adverse Reactions:

Cardiac failure, bronchospasm, asthenia, bradycardia, dizziness, arrhythmia, heart block, dyspnea, muscle weakness, cold extremities, decreased libido, chest pain, syncope, pruritus.

Note:

Formerly known under the brand name Blocadren.

How Supplied:

Contact supplier.

Indications for Timolol maleate:

Migraine prophylaxis.

Adult:

Initially 10mg twice a day. Increase weekly if needed; max 30mg daily in 2 divided doses. Evaluate at 6–8 wks.

Children:

Not recommended.

Contraindications:

Asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Cerebrovascular insufficiency. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hypotension, bradycardia with catecholamine-depleting drugs. May increase cardiac effects of calcium channel blockers, digitalis. May be potentiated by quinidine. Increased rebound hypertension with clonidine withdrawal. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine.

Pharmacological Class:

Beta-blocker.

Adverse Reactions:

Cardiac failure, bronchospasm, asthenia, bradycardia, dizziness, arrhythmia, heart block, dyspnea, muscle weakness, cold extremities, depression, decreased libido, chest pain, syncope, pruritus.

Note:

Formerly known under the brand name Blocadren.

How Supplied:

Contact supplier.

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