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TIAZAC
Angina
Hypertension
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Drug Name:

TIAZAC Rx

Generic Name and Formulations:
Diltiazem HCl 120mg, 180mg, 240mg, 300mg, 360mg, 420mg; ext rel beads in caps.

Company:
Allergan

Therapeutic Use:

Indications for TIAZAC:

Chronic stable angina.

Adult:

May sprinkle contents on applesauce; do not crush or chew contents. Initially 120–180mg once daily; adjust at 1–2 week intervals; usual max 540mg/day.

Children:

Not recommended.

Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Severe hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

Warnings/Precautions:

Heart failure. Hypotension. Impaired renal or hepatic function. Monitor liver function. Discontinue if persistent rash occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, ivabradine (avoid), simvastatin (limit simvastatin dose to 10mg/day), quinidine; consider dose adjustments; monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.

Pharmacological Class:

Calcium channel blocker (CCB) (benzothiazepine).

Adverse Reactions:

Headache, pain, dizziness, edema, asthenia, bradycardia, dyspepsia, dyspnea, bronchitis, AV block; CHF, liver abnormalities (rare).

Generic Availability:

YES

How Supplied:

Caps—30, 90, 1000

Indications for TIAZAC:

Hypertension.

Adult:

May sprinkle contents on applesauce; do not crush or chew contents. Initially 120–240mg once daily; adjust at 2-week intervals; usual max 540mg/day.

Children:

Not recommended.

Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Severe hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

Warnings/Precautions:

Heart failure. Impaired renal or hepatic function. Monitor liver function. Discontinue if persistent rash occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, ivabradine (avoid), simvastatin (limit simvastatin dose to 10mg/day), quinidine; consider dose adjustments; monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.

Pharmacological Class:

Calcium channel blocker (CCB) (benzothiazepine).

Adverse Reactions:

Edema, headache, dizziness, asthenia, 1st-degree AV block, bradycardia, flushing, nausea, rash; CHF, liver abnormalities (rare).

Generic Availability:

YES

How Supplied:

Caps—30, 90, 1000

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