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SIVEXTRO INJECTION
Bacterial infections
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Drug Name:

SIVEXTRO INJECTION Rx

Generic Name and Formulations:
Tedizolid phosphate 200mg; lyophilized pwd for IV infusion after reconstitution; preservative-free.

Company:
Cubist Pharmaceuticals, Inc.

Therapeutic Use:

Indications for SIVEXTRO INJECTION:

Susceptible acute bacterial skin and skin structure infections (ABSSSI).

Adult:

≥18yrs: Infuse 200mg once daily over 1 hour for 6 days. Switching from IV to oral: no dose adjustment necessary.

Children:

<18yrs: not established.

Warnings/Precautions:

Not adequately evaluated in patients with neutropenia (ANC <1000 cells/mm3); consider alternate therapies. Risk of C. difficile-associated diarrhea; discontinue if suspected or confirmed. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Tabs: May potentiate oral BCRP substrates; consider interrupting co-administered substrates esp. those with narrow therapeutic index (eg, methotrexate, topotecan); monitor if coadministration (including rosuvastatin) is necessary.

See Also:

SIVEXTRO

Pharmacological Class:

Oxazolidinone.

Adverse Reactions:

Nausea, headache, diarrhea, vomiting, dizziness.

Generic Availability:

NO

How Supplied:

Tabs—6 (blister pack), 30; single-use vials—10

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