Rheumatology

Guidelines for Biosimilar Use for Treatment of Rheumatologic Diseases

Guidelines for Biosimilar Use for Treatment of Rheumatologic Diseases

By

Consensus recommendations on the use of biosimilars for the treatment of patients with rheumatologic diseases were recently published in Annals of the Rheumatic Diseases.

Ketoprofen Safe, Effective Pain Management for Rheumatoid Arthritis

Ketoprofen Safe, Effective Pain Management for Rheumatoid Arthritis

By

Ketoprofen was found to be effective in relieving moderate to severe pain in patients with rheumatoid arthritis.

No Increased Risk of SLE With Current Use of Statin Therapy

No Increased Risk of SLE With Current Use of Statin Therapy

By

No association was found between current statin use and the risk of developing systemic lupus erythematosus.

SLE Disease Flares Associated With Childhood Diffuse Alveolar Hemorrhage

SLE Disease Flares Associated With Childhood Diffuse Alveolar Hemorrhage

By

Diffuse alveolar hemorrhage in childhood-onset SLE is associated with serious disease flares, and is complicated by sepsis and high mortality rate.

New SLE Candidate Criteria

New SLE Candidate Criteria

By

Researchers have created a set of 21 candidate criteria for systemic lupus erythematosus as apart of a multiphase development of a set of criteria for the disease.

FDA Approves Duzallo, Lesinurad Plus Allopurinol Combo Drug, for Gout

FDA Approves Duzallo, Lesinurad Plus Allopurinol Combo Drug, for Gout

By

The FDA approved Duzallo, a fixed-dose tablet combining lesinurad and allopurinol, for the treatment of uncontrolled gout.

Disease Activity Biomarker in Pediatric SLE

Disease Activity Biomarker in Pediatric SLE

By

Fractional exhaled nitric oxide monitoring may provide a potential biomarker of disease activity and signify the emergency of pulmonary involvement in children with SLE.

Certain Osteoporotic Drugs Effective in Preventing Secondary Vertebral Fractures

Certain Osteoporotic Drugs Effective in Preventing Secondary Vertebral Fractures

By

Clinicians who treat osteoporotic fractures should prescribe anti-osteoporotic drugs to prevent secondary vertebral and non-vertebral fractures.

Synovitis Detected by Ultrasound in Psoriatic Arthritis in Remission

Synovitis Detected by Ultrasound in Psoriatic Arthritis in Remission

By

Underlying synovitis and enthesitis may go undetected in clinical findings, but can be detected by power Doppler ultrasounds.

Association Between Low Levels of Blimp-1 Protein, Lupus

Association Between Low Levels of Blimp-1 Protein, Lupus

Researchers from the Feinstein Institute for Medical Research may have identified a potential cause for lupus, which may lead to new treatment options.

Biomarkers of Increased PAH Risk Identified in Patients With SLE

Biomarkers of Increased PAH Risk Identified in Patients With SLE

By

The risk for death associated with SLE remains high for patients with SLE-associated PAH and researchers have identified the biomarkers that may lead to early detection.

Early CVD Detection in Patients With RA: Expert Insight

Early CVD Detection in Patients With RA: Expert Insight

By

Patients with RA have a significantly higher risk of cardiovascular disease, and cardiac magnetic resonance can help with early diagnosis.

Disease Activity on Foot MRI Despite Clinical Remission in Rheumatoid Arthritis

Disease Activity on Foot MRI Despite Clinical Remission in Rheumatoid Arthritis

By

A sizeable percentage of patients with rheumatoid arthritis who are in clinical remission have evidence of disease activity on magnetic resonance imaging of the foot that is mostly affected.

Fish Consumption May Reduce RA Symptoms

Fish Consumption May Reduce RA Symptoms

Eating fish at least twice a week may significantly reduce the pain and swelling associated with rheumatoid arthritis.

Lesinurad Plus Febuxostat for Tophaceous Gout

Lesinurad Plus Febuxostat for Tophaceous Gout

In patients with tophaceous gout, combination therapy of lesinurad plus febuxostat is more effective at reducing serum urate levels than febuxostat monotherapy.

Risk Factor for Osteonecrosis in Patients With SLE

Risk Factor for Osteonecrosis in Patients With SLE

By

Cumulative steroid dosage is a risk factor for the development of osteonecrosis, which is the most frequent type of damage in lupus patients.

Opioid Use Patterns in Rheumatoid Arthritis

Opioid Use Patterns in Rheumatoid Arthritis

By

Longitudinal opioid prescribing patterns suggest that regular use among patients with rheumatoid arthritis (RA) is slightly declining.

Subcutaneous Belimumab Effective on SLE

Subcutaneous Belimumab Effective on SLE

By

Adjunctive subcutaneous belimumab plus standard care improves SLE Responder Index response and decreases disease flares

Detecting Cognitive Dysfunction in Systemic Lupus Erythematosus

Detecting Cognitive Dysfunction in Systemic Lupus Erythematosus

By

The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination at detecting cognitive dysfunction in SLE.

Lesinurad Plus Febuxostat Effective for Tophaceous Gout

Lesinurad Plus Febuxostat Effective for Tophaceous Gout

By

Lesinurad combined with febuxostat showed superior serum urate reduction vs febuxostat alone in patients with tophaceous gout requiring additional therapy.

Dose-Dependent ACR20 Response Rates in RA With Peficitinib

Dose-Dependent ACR20 Response Rates in RA With Peficitinib

By

Use of the JAK inhibitor peficitinib in combination with certain csDMARDs results in a dose-dependent ACR20 response rate in patients with RA over 12 weeks.

Diagnostic Value of MRI for Unclassified Arthritis

Diagnostic Value of MRI for Unclassified Arthritis

MRI may assist in identifying patients with unclassified arthritis who will develop rheumatoid arthritis (RA) — primarily in patients with UA presenting with oligoarthritis.

Association Between Osteoporosis and Multiple Sclerosis

Association Between Osteoporosis and Multiple Sclerosis

By

Patients with multiple sclerosis (MS) have lower bone mineral density and greater rates of osteoporosis than healthy controls.

Low Disease Activity in Rheumatoid Arthritis After Tofacitinib Discontinuation

Low Disease Activity in Rheumatoid Arthritis After Tofacitinib Discontinuation

By

Approximately 1 in 3 patients with RA who discontinued tofacitinib maintained low disease activity after 1 year.

Additional Tool for Juvenile Dermatomyositis Diagnosis: Muscle MRI

Additional Tool for Juvenile Dermatomyositis Diagnosis: Muscle MRI

By

Muscle MRI may complement a physician's objective assessment in juvenile dermatomyositis, although negative MRI findings should not preclude treatment continuation.

Gout Prevention With Dietary Intervention

Gout Prevention With Dietary Intervention

The Dietary Approaches to Stop Hypertension (DASH) diet is effective for prevention of gout.

Serum Uric Acid Levels Associated With Gout Risk

Serum Uric Acid Levels Associated With Gout Risk

By

High serum uric acid levels are associated with a high risk of new-onset gout and gout recurrence, while lowering SUA levels can significantly reduce incident and recurrent gout.

Concern Regarding Legislation Allowing Substitution of Biosimilars for Branded Drugs

Concern Regarding Legislation Allowing Substitution of Biosimilars for Branded Drugs

Much concern has been voiced regarding legislation allowing the substitution of biosimilars for branded drugs.

Alterations in Soluble Mediators May Predict Transition to Lupus

Alterations in Soluble Mediators May Predict Transition to Lupus

Preclinical alterations in levels of soluble mediators may predict transition to SLE for unaffected relatives of patients with SLE.

Rheumatoid Arthritis Treatment: Baricitinib Superior to Adalimumab

Rheumatoid Arthritis Treatment: Baricitinib Superior to Adalimumab

By

This study included phase 3 trial in patients taking baricitinib, adalimumab, or placebo in addition to methotrexate background therapy.

Sign Up for Free e-Newsletters