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RENAGEL TABLETS
Hyperphosphatemia
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Drug Name:

RENAGEL TABLETS Rx

Generic Name and Formulations:
Sevelamer HCl 400mg, 800mg.

Company:
Sanofi Genzyme Company

Therapeutic Use:

Indications for RENAGEL TABLETS:

Control of serum phosphorus in patients with chronic kidney disease on dialysis.

Adult:

Swallow whole with meals. Patients not taking a phosphate binder: serum phosphorus >5.5 to <7.5mg/dL: 800mg 3 times daily; 7.5–<9mg/dL: 1.2–1.6g 3 times daily; ≥9mg/dL: 1.6g 3 times daily. Titrate by 1 tab per meal at 2-week intervals to keep serum phosphorus ≤5.5mg/dL. Switching from calcium acetate to sevelamer: see full labeling.

Children:

Not established.

Contraindications:

Bowel obstruction.

Warnings/Precautions:

Dysphagia. Swallowing disorders. Severe GI motility disorders. Major GI tract surgery. Monitor serum bicarbonate, chloride. Pregnancy (Cat.C).

Interactions:

Concomitant with drugs that have a narrow therapeutic index; monitor. Consider separation of administration with cyclosporine, tacrolimus, or levothyroxine. Separate dosing of ciprofloxacin by ≥2hrs before or 6hrs after sevelamer; mycophenolate mofetil by ≥2hrs before sevelamer.

Pharmacological Class:

Phosphate binder.

Adverse Reactions:

Vomiting, nausea, diarrhea, dyspepsia, abdominal pain, flatulence, constipation; rare: bowel obstruction, perforation.

How Supplied:

Tabs 400mg—360; 800mg—180

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