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Promethazine HCl Rectal Suppositories
Nausea
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Drug Name:

Promethazine HCl Rectal Suppositories Rx

Generic Name and Formulations:
Promethazine HCl 12.5mg, 25mg, 50mg.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Promethazine HCl Rectal Suppositories:

Motion sickness. Perioperative nausea & vomiting.

Adult:

Motion sickness: 25mg 30–60mins before travel; may repeat in 8–12hrs; maintenance 25mg twice daily. Perioperative nausea & vomiting: 25mg; may give additional doses of 12.5–25mg at 4–6hr intervals.

Children:

<2yrs: see Contraindications. Motion sickness: ≥2yrs: 12.5–25mg twice daily. Perioperative nausea & vomiting: 0.5mg/lb or 25mg; may give additional doses of 12.5–25mg or 0.5mg/lb at 4–6hr intervals.

Contraindications:

Children <2yrs. Dehydrated or ill children (esp. Reye's syndrome). History of sleep apnea. Asthma and lower respiratory disorders. Uncomplicated nausea in children.

Warnings/Precautions:

Glaucoma. GI or urinary obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Children ≥2yrs. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Caution with MAOIs. May alter hCG pregnancy test results.

See Also:

Promethazine HCl Tablets

Pharmacological Class:

Phenothiazine.

Adverse Reactions:

Drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, neonatal platelet abnormalities; children: respiratory depression (may be fatal).

Note:

Formerly known under the brand names Phenergan (tabs, supps); Promethacon (supps).

How Supplied:

Contact supplier.

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