Additionally, statistical significance vs placebo was also achieved in total postsurgical opioid consumption through 48 hours (P<0.0001); opioid-free subjects through 48 hours (P<0.01); and time to first opioid rescue through 48 hours (P<0.0001).
Preoperative chronic opioid use is associated with poor outcomes and continued dependence after posterior lumbar fusion.
Multimodal analgesia after hip or knee arthroplasty may be associated with fewer complications and reduced opioid prescriptions and hospital length of stay, compared with unimodal analgesia.
In a preliminary study, high-frequency spinal cord stimulation was found to be more effective in treating chronic pain than conventional stimulation.
Intravenous acetaminophen with or without ketorolac is associated with reduced opioid consumption and cost of care after scoliosis surgery in adolescents.
Ilioinguinal-Transversus Abdominis Plane Block When Standard Analgesia Fails After Cesarean DeliveryFebruary 23, 2018
Ilioinguinal-transversus abdominis plane block was shown to provide superior pain relief compared with a multimodal analgesic regimen in patients undergoing an elective cesarean delivery.
Clinical best practice recommendations for the use of buprenorphine in the perioperative management of patients undergoing interventional pain procedures and other surgeries were recently published.
The most promising tools to predict acute pain after cesarean delivery are local anesthetic infiltration before placement of spinal anesthesia, and asking patients simple questions about anticipated pain and analgesic needs.
The FDA has accepted a New Drug Application for an investigational topical twice-a-day product for the treatment of inflammation and pain in patients who have undergone ocular surgery.
Intravenous Acetaminophen May Reduce Hospital Length of Stay in Adolescents Undergoing Posterior Spinal FusionJanuary 16, 2018
Postoperative management of adolescents undergoing posterior spinal fusion surgery with intravenous acetaminophen may have an opioid-sparing effect, due to a reduced hospital length of stay.
Genetics may be a factor in the experience of chronic postoperative pain as 42 polymorphisms were found to be correlated with chronic postsurgical pain.
Preoperative levels of serum total cholesterol do not correlate with postoperative pain following laparoscopic surgery for gastric cancer.
Parent- and nurse-controlled analgesia may not reduce postoperative pain in children with developmental delay compared with opioids administered by a nurse as needed.
Abstinent smokers may have reduced preoperative pain tolerance and increased postoperative opioid use compared with nonsmokers.
The FDA has granted Fast Track Designation to the investigational treatment CA-008 (Concentric Analgesics) for the treatment of post-surgical pain.
Systematic Review Does Not Identify Patient-Related Risk Factors for Chronic Pain After Total Knee Replacement SurgeryDecember 12, 2017
There is little evidence to suggest that postoperative knee pain, knee function, or various psychosocial factors influence long-term chronic pain following total knee replacement.
Esmolol was shown to reduce the use of opioids during and after surgery without having a significant impact on postoperative pain scores.
Opioid treatment of acute postoperative pain was shown to cause high rates of postoperative nausea and vomiting, particularly in women and younger patients.
Elevated rates of new persistent opioid use were found in patients undergoing both minor and major surgical procedures.
A number of shortcomings are associated with systematic reviews and meta-analyses of postoperative care.
There was a correlation for consistent vitamin D supplementation with increase in physical component of the SF-12 score.
An association was found between sleep quality and next-day pain intensity in children undergoing major surgery.
A standardized process for data analysis and internal benchmarking facilitated a reduction in pain following hip arthroplasty.
Psychological factors may influence the severity and duration of pain following surgery.
The usefulness of sPNB is limited due to the short duration of action, while a major limitation of cPNB is the significant investment.
Parents' experiences impacted by need to balance pros and cons of administering medicines.
Ropivacaine linked to reduced postoperative opioid consumption, pain versus placebo
Clinical Pain Advisor Articles
- Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain
- Tackling the Chronic Pain and Opioid Use Disorder Crises Through Public-Private Partnerships
- How the City of San Francisco Is Tackling the Intertwined HIV/HCV and Opioid Epidemics
- Pain Tolerance in Buprenorphine Maintenance Treatment
- The State of Drug Storage, Disposal Labeling Information for Opioid Analgesics
- Radiofrequency Ablation for Chronic Hip Pain: Reviewing the Evidence
- Opioid Use Disorder Treatment: Evidence-Based Guideline
- Betel Quid Addiction and Implications for Substance Use Disorder
- Low Back Pain: Contributing Factors, Prophylactic Strategies, and Effective Treatments
- Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain
- Predicting Suicidal Ideation in Veterans With Chronic Pain
- Femoral Nerve Block Alone or in Combination With Sciatic Nerve Block for TKA: A Meta-Analysis
- Improved Care Efficiency Requires a More Manageable System
- Recommendations Developed on Gender Equity in Medicine
- Medication Adherence, Blood Pressure Reduction Assessed With Smartphone App Use